Description
Repaglinide is a derivative of meglitinide that non-selectively binds the sulfonylurea subunit of ATP-sensitive K+ channels, inducing channel closure. Repaglinide is a fast acting anti-diabetic compound that increases insulin release.
Product Unit Size | Cost | Quantity | Stock |
---|
Repaglinide is a derivative of meglitinide that non-selectively binds the sulfonylurea subunit of ATP-sensitive K+ channels, inducing channel closure. Repaglinide is a fast acting anti-diabetic compound that increases insulin release.
Cas No. | 135062-02-1 |
---|---|
Purity | ≥98% |
Formula | C27H36N2O4 |
Formula Wt. | 452.59 |
Chemical Name | 2-ethoxy-4-[2-[[(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butyl]amino]-2-oxoethyl]benzoic acid |
IUPAC Name | 2-ethoxy-4-[2-[[(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butyl]amino]-2- oxoethyl]benzoic acid |
Melting Point | 130-131°C |
Appearance | White to off white powder |
Store Temp | Ambient |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Zünkler BJ. Human ether-a-go-go-related (HERG) gene and ATP-sensitive potassium channels as targets for adverse drug effects. Pharmacol Ther. 2006 Oct;112(1):12-37. PMID: 16647758.
Proks P, Reimann F, Green N, et al. Sulfonylurea stimulation of insulin secretion. Diabetes. 2002 Dec;51 Suppl 3:S368-76. PMID: 12475777.
Hatorp V. Clinical pharmacokinetics and pharmacodynamics of repaglinide. Clin Pharmacokinet. 2002;41(7):471-83. PMID: 12083976.
NSAID; COX-2 inhibitor.
Nucleoside (guanosine) analog; DNA chain termin...
Triadimefon metabolite; mutagen.
SERM.
Melatonin analog; MT1/2 agonist, 5-HT2C antagon...
Synthesis intermediate
5-HT3 antagonist.
EGFR inhibitor.
Nav1.7 and Nav1.8 N1+ channel blocker.
Synthetic somatostatin analog, peptide; somatos...
Non-depolarizing NMJ blocker; nAChR antagonist....
Naphthalene; indirect STAT1 agonist.
Bisphosphonate; inhibits transfer of farnesyl p...
α7 and β4 nAChR agonist, α4β2 and α6β2 nA...
Dual inhibitor of p70S6K and Akt.
CDK4/6 inhibitor.
Endogenous peptide hormone inolved in gastric e...
Quinolone alkaloid precursor of irinotecan, ori...
NO donor; annexin A2 inhibitor.
Protein translation inhibitor, peptidyl transfe...