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BLZ-945

BLZ-945

Product ID B4796
Cas No. 953769-46-5
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $106.40 In stock
5 mg $319.00 In stock
25 mg $968.90 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

BLZ945 is an inhibitor of the CSF-1R kinase receptor; it exhibits immunostimulatory and anticancer chemotherapeutic activities and prevents skeletal metastasis of diseases. BLZ945 prevents turnover of tumor-associated macrophages and increases CD8+ T cell levels, limiting tumor growth in animal models of mammary carcinogenesis.

Product Info

Cas No.

953769-46-5

Purity

≥95%

Formula

C20H22N4O3S

Formula Wt.

398.48

Chemical Name

4-[(2-{[(1R,2R)-2-Hydroxycyclohexyl]amino}-1,3-benzothiazol-6-yl)oxy]-N-methyl-2-pyridinecarboxamide

IUPAC Name

4-[(2-{[(1R,2R)-2-Hydroxycyclohexyl]amino}-1,3-benzothiazol-6-yl)oxy]-N-methyl-2-pyridinecarboxamide

Synonym

BLZ945

Solubility

Soluble in DMSO. Slightly soluble in ethanol. Insoluble in water.

Appearance

Pale yellow solid.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

B4796 MSDS PDF

Info Sheet

B4796 Info Sheet PDF

References

Krauser JA, Jin Y, Walles M, et al. Phenotypic and metabolic investigation of a CSF-1R kinase receptor inhibitor (BLZ945) and its pharmacologically active metabolite. Xenobiotica. 2015 Feb;45(2):107-23. PMID: 25180976.

Strachan DC, Ruffell B, Oei Y, et al. CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+ T cells. Oncoimmunology. 2013 Dec 1;2(12):e26968. PMID: 24498562.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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