LKT Labs

Biochemicals for Life Science Research

Loganin

Product ID L5624
Cas No. 18524-94-2
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $83.40 In stock
25 mg $166.60 In stock
100 mg $555.70 In stock
Bulk Quote

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Description

Loganin is an iridoid glucoside found in the Cornus officialis plant. Loganin displays anti-inflammatory, antioxidative, cognition enhancing, and neuroprotective activities. Loganin inhibits β-secretase in vitro and increases performance in Morris water maze and Y-maze tests in vivo, suggesting potential benefit in memory impairment and Alzheimer’s disease. This compound also modulates ERK signaling to decrease connective tissue growth factor and downregulates expression of MCP-1, NF-κB, and iNOS in animal models.

Product Info

Cas No.

18524-94-2
Purity

≥98%
Formula

C17H26O10
Formula Wt.

390.38
Chemical Name

Methyl (1S,4aS,6S,7R,7aS)-1-(beta-D-glucopyranosyloxy)-6-hydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate
IUPAC Name

methyl (1S,4aS,6S,7R,7aS)-6-hydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4, 5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,6,7, 7a-hexahydrocyclopenta[c]pyran-4-carboxylate
Synonym

7-Hydroxy-6-desoxyverbenalin, (1S,4aS,6S,7R,7aS)-6-Hydroxy-1-((1S,4R,5S)-5-hydroxy-4-(S)-hydroxy-3-(R)-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-7-methyl-1,4a,5,6,7,7a-hexahydro-cyclopenta[c]pyran-4-carboxylic acid methyl ester
Melting Point

222°C
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

L5624 MSDS PDF
Info Sheet

L5624 Info Sheet PDF

References

Youn K, Jeong WS, Jun M. β-Secretase (BACE1) inhibitory property of loganin isolated from Corni fructus. Nat Prod Res. 2013 Aug;27(16):1471-4. PMID: 22931211.

Jiang WL, Zhang SP, Hou J, et al. Effect of loganin on experimental diabetic nephropathy. Phytomedicine. 2012 Feb 15;19(3-4):217-22. PMID: 21978885.

Park CH, Tanaka T, Kim JH, et al. Hepato-protective effects of loganin, iridoid glycoside from Corni Fructus, against hyperglycemia-activated signaling pathway in liver of type 2 diabetic db/db mice. Toxicology. 2011 Nov 28;290(1):14-21. PMID: 21864639.

Kwon SH, Kim HC, Lee SY, et al. Loganin improves learning and memory impairments induced by scopolamine in mice. Eur J Pharmacol. 2009 Oct 1;619(1-3):44-9. PMID: 19666019.

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