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EPZ6438

Product ID E6397
Cas No. 1403254-99-8
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $50.00 In stock
5 mg $93.70 In stock
25 mg $247.50 Please Inquire
100 mg $750.20 Please Inquire
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  • Product Info
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  • Description
  • Product Info
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Description

EPZ-6438 is an inhibitor of EZH2, a histone methyltransferase (HMT) responsible for methylation of lysine and arginine residues and controls gene transcription fidelity in cells. EPZ-6438 displays anticancer chemotherapeutic activity in in vivo models by inducing regression of malignant or atypical teratoid rhabdoid tumors containing altered or mutant SWI/SNF ATP-dependent chromatin remodelers.

Product Info

Cas No.

1403254-99-8

Purity

≥99%

Formula

C34H44N4O4

Formula Wt.

572.74

Chemical Name

N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide

IUPAC Name

N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide

Synonym

E7438, Tazemetostat,

Solubility

DMSO 5 mg/mL warmed (8.72 mM) Water Insoluble Ethanol Insoluble

Appearance

white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

E6397 MSDS PDF

Info Sheet

E6397 Info Sheet PDF

Brochures

Epigenetic Modifiers Booklet

References

Knutson SK, Warholic NM, Wigle TJ, et al. Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7922-7. PMID: 23620515.

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