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NMS-E628

NMS-E628

Product ID N4974
Cas No. 1108743-60-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $67.80 In stock
5 mg $188.00 In stock
10 mg $315.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

NMS-E628 (entrectinib) is an inhibitor of ALK anaplastic lymphoma kinase (ALK) and Ros1 and an antagonist at Trk receptors; it exhibits anticancer chemotherapeutic activity. Clinically, this compound suppresses tumor growth in non-small cell lung cancer (NSCLC) subjects with NTRK1 gene rearrangements.

Product Info

Cas No.

1108743-60-7

Purity

≥98%

Formula

C31H34F2N6O2

Formula Wt.

560.64

Chemical Name

N-[5-(3,5-Difluorobenzyl)-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-(tetrahydro-2H-pyran-4-ylamino)benzamide

IUPAC Name

N-[5-(3,5-Difluorobenzyl)-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-(tetrahydro-2H-pyran-4-ylamino)benzamide

Synonym

Entrectinib, RXDX-101

Solubility

DMSO,100mg/mL Ethanol,100mg/mL Water,<1mg/mL

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

N4974 MSDS PDF

Info Sheet

N4974 Info Sheet PDF

References

Amatu A, Somaschini A, Cerea G, et al. Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer. Br J Cancer. 2015 Dec 3. [Epub ahead of print]. PMID: 26633560.

Farago AF, Le LP, Zheng Z, et al. Durable Clinical Response to Entrectinib in NTRK1-Rearranged Non-Small Cell Lung Cancer. J Thorac Oncol. 2015 Nov 12. [Epub ahead of print]. PMID: 26565381.

Rolfo C, Ruiz R, Giovannetti E, et al. Entrectinib: a potent new TRK, ROS1, and ALK inhibitor. Expert Opin Investig Drugs. 2015 Nov;24(11):1493-500. PMID: 26457764.

Custom Order

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