Amiodarone Hydrochloride

Name: Amiodarone Hydrochloride
SKU: A5037
Availability: InStock

Product ID A5037

Cas No. 19774-82-4

Purity ≥98%

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Description
Product Info
Shipping and Storage
Downloads
References

Description

Amiodarone is a class III anti-arrhythmic that inhibits Na+ channels, voltage-gated Ca2+ channels, voltage-gated K+ channels, and α/β-adrenergic receptors. Amiodarone prolongs the duration of the action potential, increasing the length of the refractory period; it is clinically used to treat ventricular fibrillation and ventricular tachycardia. Amiodarone also exhibits antiviral activity, inhibiting cell entry by filovirus, guanarito virus, and hepatitis C. Additionally, this compound acts as a functional inhibitor of acid sphingomyelinase (FIASMA).

Product Info

Cas No.	19774-82-4
Purity	≥98%
Formula	C₂₅H₂₉I₂NO₃ • HCl
Formula Wt.	681.78
Chemical Name	(2-Butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone hydrochloride
IUPAC Name	(2-butyl-1-benzofuran-3-yl)-[4-[2-(diethylamino)ethoxy]-3, 5-diiodophenyl]methanone;hydrochloride
Synonym	Amiodar, Ancaron, Cordarone, Ortacrone, Tachydaron, Trangorex
Melting Point	156°C
Solubility	Soluble in methanol, chloroform, and methylene chloride. Slightly soluble in acetone and dioxane. Sparingly soluble in isopropanol.
Appearance	White or almost white Crystal Powder

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	A5037 MSDS PDF
Info Sheet	A5037 Info Sheet PDF

References

Zoerner F, Semenas E. Resuscitation with amiodarone increases survival after hemorrhage and ventricular fibrillation in pigs. J Trauma Acute Care Surg. 2014 Jun;76(6):1402-8. PMID: 24854308.

Gehring G, Rohrmann K, Atenchong N, et al. The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry. J Antimicrob Chemother. 2014 Apr 7. [Epub ahead of print]. PMID: 24710028.

Cheng YL, Lan KH, Lee WP, et al. Amiodarone inhibits the entry and assembly steps of hepatitis C virus life cycle. Clin Sci (Lond). 2013 Nov;125(9):439-48. PMID: 23659500.