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Luteinizing hormone-releasing hormone (LHRH or Gonadotropin-releasing hormone [GnRH]) is an endogenous peptide hormone that binds the GnRH receptor, stimulating secretion of reproductive hormones (such as luteinizing hormone [LH] and follicle-stimulating hormone [FSH]) from the pituitary gland. Analogs of GnRH are clinically used to treat hormone-dependent diseases such as prostate and breast cancer, hyperplasia, and endometriosis.
| Cas No. | 33515-09-2 |
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| Purity | ≥95% |
| Formula Wt. | 1182.31 |
| Chemical Name | pEHWSYGLRPG-NH₂ |
| IUPAC Name | (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide |
| Synonym | Gonadorelin, Gonadorelin acetate salt, Luliberin, GnRH, LH-RH, human |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Limonta P, Manea M. Gonadotropin-releasing hormone receptors as molecular therapeutic targets in prostate cancer: Current options and emerging strategies. Cancer Treat Rev. 2013 Oct;39(6):647-63. PMID: 23290320.
Millar RP, Newton CL. Current and future applications of GnRH, kisspeptin and neurokinin B analogues. Nat Rev Endocrinol. 2013 Aug;9(8):451-66. PMID: 23817290.
Wu HM, Wang HS, Huang HY, et al. Gonadotropin-releasing hormone type II (GnRH-II) agonist regulates the invasiveness of endometrial cancer cells through the GnRH-I receptor and mitogen-activated protein kinase (MAPK)-dependent activation of matrix metalloproteinase (MMP)-2. BMC Cancer. 2013 Jun 20;13:300. PMID: 23786715.
Burel D, Li JH, Do-Rego JL, et al. Gonadotropin-releasing hormone stimulates the biosynthesis of pregnenolone sulfate and dehydroepiandrosterone sulfate in the hypothalamus. Endocrinology. 2013 Jun;154(6):2114-28. PMID: 23554453.