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VX-765

Product ID V9228
Cas No. 273404-37-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $108.00 Please Inquire
5 mg $179.80 Please Inquire
10 mg $278.70 In stock
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  • Product Info
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  • References
  • Description
  • Product Info
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  • Downloads
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Description

VX-765 is an inhibitor of NLRP3 inflammasome activity; it inhibits caspase 1 and IL-1β cleavage and release. VX-765 exhibits anti-inflammatory, antidepressant, and antiepileptic activities. In vivo, this compound decreases IL-1β levels and attenuates stress-induced depression-like behaviors. In animal models of status epilepticus, VX-765 decreases cell loss. In other similar animal models, this compound decreases chronic epileptic activity and delays onset of acute seizures.

Product Info

Cas No.

273404-37-8

Purity

≥98%

Formula

C24H33ClN4O6

Formula Wt.

509.00

IUPAC Name

N-(4-Amino-3-chlorobenzoyl)-3-methylvalyl-N-[(2R,3S)-2-ethoxy-5-oxotetrahydro-3-furanyl]-L-prolinamide

Synonym

VX765,Belnacasan

Solubility

DMSO 100 mg/mL warmed (196.46 mM) Ethanol 100 mg/mL warmed (196.46 mM) Water Insoluble

Appearance

Light yellow powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

V9228 MSDS PDF

Info Sheet

V9228 Info Sheet PDF

References

Zhang Y, Liu L, Liu YZ, et al. NLRP3 Inflammasome Mediates Chronic Mild Stress-induced Depression in Mice via Neuroinflammation. Int J Neuropsychopharmacol. 2015 Jan 20. [Epub ahead of print]. PMID: 25603858.

Kaminski RM, Rogawski MA, Klitgaard H. The potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments. Neurotherapeutics. 2014 Apr;11(2):385-400. PMID: 24671870.

Noe FM, Polascheck N, Frigerio F, et al. Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy. Neurobiol Dis. 2013 Nov;59:183-93. PMID: 23938763.

Maroso M, Balosso S, Ravizza T, et al. Interleukin-1β biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice. Neurotherapeutics. 2011 Apr;8(2):304-15. PMID: 21431948.

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