LKT Labs

Biochemicals for Life Science Research

Baclofen

Product ID B0110
Cas No. 1134-47-0
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $55.40 In stock
5 g $185.30 In stock
10 g $305.70 In stock
Bulk Quote

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Description

Baclofen is a GABA derivative that acts as an agonist at GABA-B receptors; it is commonly used in animal models to examine the effects of GABAergic neurotransmission in a variety of fields, including substance dependence, spasticity, pain, and feeding behavior. Baclofen exhibits analgesic, antinociceptive, and antiepileptic/anticonvulsant activities. The analgesic effect of baclofen is mediated by its GABA-B receptor activation, inducing a presynaptic block of action potentials induced by mechanical or thermal stimuli that decreases frequency and amplitude of excitatory post-synaptic currents. Baclofen is used clinically to promote abstinence in alcohol dependent subjects, potentially mediating alcohol craving during withdrawal. This compound is also delivered intrathecally to treat spasticity and dystonia.

Product Info

Cas No.

1134-47-0
Purity

≥98%
Formula

C10H12ClNO2
Formula Wt.

213.66
Chemical Name

β-(Aminomethyl)-4-chlorobenzenepropanoic acid
IUPAC Name

4-amino-3-(4-chlorophenyl)butanoic acid
Synonym

Baclon, Clofen, Lioresal
Melting Point

206-208°C
Solubility

Soluble in water or 100 mM NaOH.
Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

B0110 MSDS PDF
Info Sheet

B0110 Info Sheet PDF

References

Fukuhara K, Katafuchi T, Yoshimura M. Effects of baclofen on mechanical noxious and innocuous transmission in the spinal dorsal horn of the adult rat: in vivo patch-clamp analysis. Eur J Neurosci. 2013 Aug 20. [Epub ahead of print]. PMID: 23961926.

Kumru H, Kofler M, Flores MC, et al. Effect of intrathecal baclofen on evoked pain perception: an evoked potentials and quantitative thermal testing study. Eur J Pain. 2013 Aug;17(7):1039-47. PMID: 23239275.

Brennan JL, Leung JG, Gagliardi JP, et al. Clinical effectiveness of baclofen for the treatment of alcohol dependence: a review. Clin Pharmacol. 2013 Jul 3;5:99-107. PMID: 23869179.

Uchiyama T, Nakanishi K, Fukawa N, et al. Neuromodulation using intrathecal baclofen therapy for spasticity and dystonia. Neurol Med Chir (Tokyo). 2012;52(7):463-9. PMID: 22850493.

Miner P, Borkuhova Y, Shimonova L, et al. GABA-A and GABA-B receptors mediate feeding elicited by the GABA-B agonist baclofen in the ventral tegmental area and nucleus accumbens shell in rats: reciprocal and regional interactions. Brain Res. 2010 Oct 8;1355:86-96. PMID: 20696149.

Levy RA, Proudfit HK. The analgesic action of baclofen [beta-(4-chlorophenyl)-gamma-aminobutyric acid]. J Pharmacol Exp Ther. 1977 Aug;202(2):437-45. PMID: 886473.

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