LKT Labs

Biochemicals for Life Science Research

Itraconazole

Product ID I7870
Cas No. 84625-61-6
Purity ≥98%
Product Unit SizeCostQuantityStock
50 mg $75.00 In stock
100 mg $131.10 In stock
250 mg $262.10 In stock
1 g $777.10 In stock
Bulk Quote

Quicklinks

Description

Itraconazole is a triazole antifungal that also exhibits anti-angiogenic and anticancer chemotherapeutic activities. Itraconazole inhibits synthesis of ergosterol, preventing fungal cell wall formation in Aspergillus. Itraconazole also inhibits hedgehog (Hh) signaling through activity on Smo, preventing growth of medulloblastoma tumors in vivo. Additionally, itraconazole inhibits VEGF-induced angiogenesis in other animal models. This compound also induces G1 phase cell cycle arrest in endothelial cells. Most of the biological activity of itraconazole is likely through the inhibition of 14-α demethylase.

Product Info

Cas No.

84625-61-6
Purity

≥98%
Formula

C35H38Cl2N8O4
Formula Wt.

705.63
Chemical Name

4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4- triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]- phenyl]-1-peperazinyl]phenyl]-2,4-dihydro-2-(1- methylpropyl)-3H-1,2,4-triazol-3one
IUPAC Name

2-butan-2-yl-4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2, 4-triazol-1-ylmethyl)-1, 3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2, 4-triazol-3-one
Synonym

Oriconazole, Itrizole, Sporanox, Triasporin
Melting Point

166.2°C
Solubility

Soluble in chloroform (50mg/mL). Practically insoluble in water and dilute acidic solutions. DMSO:4mg/mL
Appearance

White or almost white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

I7870 MSDS PDF
Info Sheet

I7870 Info Sheet PDF
Brochures

WNT Booklet

References

Kim J, Tang JY, Gong R, et al. Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell. 2010 Apr 13;17(4):388-99. PMID: 20385363.

Chong CR, Xu J, Lu J, et al. Inhibition of angiogenesis by the antifungal drug itraconazole. ACS Chem Biol. 2007 Apr 24;2(4):263-70. PMID: 17432820.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.