• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
(+)-Taxifolin

(+)-Taxifolin

Product ID T0394
Cas No. 480-18-2
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $56.40 In stock
25 mg $89.70 In stock
100 mg $280.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Taxifolin is a catechol-type flavonoid that displays cardioprotective, neuroprotective, antioxidative, and anticancer chemotherapeutic activities. In animal models of diabetic cardiomyopathy, taxifolin inhibits myocyte apoptosis (through inhibition of caspase-3 and caspase-9 activation, release of cytochrome c, and increases in JAK/STAT3 activation), attenuating structural pathology and improving diastolic function. Taxifolin displays neuroprotective properties in models of Alzheimer’s disease as it prevents aggregation of amyloid-β (Aβ) proteins by reacting with lysine residues. This compound also increases quinone reductase activity and decreases NADPH oxidase activity, activating the antioxidant response element (ARE). Additionally, taxifolin inhibits fatty acid synthesis and cell growth and induces apoptosis, inhibiting proliferation of cancer cells in vitro and in vivo.

Product Info

Cas No.

480-18-2

Purity

≥98%

Formula

C15H12O7

Formula Wt.

304.25

Chemical Name

(2S,3S)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one

IUPAC Name

(2S,3S)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one

Synonym

Dihydroquercetin

Melting Point

230-232°C

Solubility

DMSO (60 mg/mL); ethanol (60 mg/mL); water (<1 mg/mL).

Appearance

Light yellow powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T0394 MSDS PDF

Info Sheet

T0394 Info Sheet PDF

References

Sato M, Murakami K, Uno M, et al. Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid-beta aggregation. Biosci Biotechnol Biochem. 2013;77(5):1100-1103. PMID: 23649236.

Sun X, Chen RC, Yang ZH, et al. Taxifolin prevents diabetic cardiomyopathy in vivo and in vitro by inhibition of oxidative stress and cell apoptosis. Food Chem Toxicol. 2013 Nov 20. [Epub ahead of print]. PMID: 24269735

Sato M, Murakami K, Uno M, et al. Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues. J Biol Chem. 2013 Aug 9;288(32):23212-24. PMID: 23792961

Lee SB, Cha KH, Selenge D, et al. The chemopreventive effect of taxifolin is exerted through ARE-dependent gene regulation. Biol Pharm Bull. 2007 Jun;30(6):1074-9. PMID: 17541156

Brusselmans K, Vrolix R, Verhoeven G, et al. Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity. J Biol Chem. 2005 Feb 18;280(7):5636-45. PMID: 15533929.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B0109

    Bakuchiol

    Prenylated phenolic terpene found in various pl...

    ≥98%
  • C9614

    Cyclosporin H

    Cyclosporin metabolite; formyl peptide inhibito...

    ≥96%
  • A488240

    AMG-337

    Selective inhibitor of c-Met.

    ≥99%
  • T7056

    Troglitazone

    Thiazolidinedione; PPARγ agonist, ATP-sensitiv...

    ≥97%
  • G0096

    GAY

    Tripeptide, used to tag proteins.

    ≥95%
  • M577521

    Monascorubrin

    Bulgarialactone azaphilone

    ≥98%
  • D760022

    DT-2216

    BCL-XL specific degrader

    ≥98%
  • P2817

    Phentolamine Hydrochloride

    ATP-sensitive K+ channel activator, α-adrenerg...

    ≥98%
  • M324083

    Micafungin

    Echinocandin

    ≥95%
  • P2508

    Phenethyl Isothiocyanate

    ITC found in cruciferous vegetables.

    ≥99%
  • C2951

    Chlortetracycline Hydrochloride

    Tetracycline; protein translation inhibitor, MM...

    ≥85%
  • Z4833

    ZM-336372

    c-Raf inhibitor, tyrosine kinase inhibitor.

    ≥98%
  • C2944

    Chlorogenic Acid (from Lonicera)

    Polyphenol derivative of caffeic acid found in ...

    ≥99%
  • A7672

    Atropine Sulfate Monohydrate

    Tropane alkaloid found in Solanaceae plants; mA...

    ≥98%
  • F5872

    N-formyl-Nle-Leu-Phe-Nle-Tyr-Lys

    Peptide, involved in neutrophil activation; FPR...

    ≥95%
  • A6058

    Apoptosis Activator 2

    Apoptosis inducing agent.

    ≥98%
  • P7021

    Prednisone Acetate

    Synthetic prednisolone prodrug; glucocorticoid ...

    ≥98%
  • G691343

    Griseofulvin

    Fungistatic

    ≥98%
  • S1971

    Sertraline Hydrochloride

    FIASMA, SERT and DAT inhibitor, α1-adrenergic ...

    ≥98%
  • T6902

    Tranilast

    Mast cell stabilizer; TRPV2 antagonist, PDGFR i...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only