LKT Labs

Biochemicals for Life Science Research

Atropine Sulfate Monohydrate

Product ID A7672
Cas No. 5908-99-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $120.30 In stock
10 g $185.30 In stock
25 g $294.30 In stock
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Description

Atropine is a tropane alkaloid found in plants in the Solanaceae family. Atropine is an anticholinergic compound that also exhibits analgesic and antinociceptive activity. Atropine is a competitive inhibitor of muscarinic acetylcholine receptors (mAChRs) that is commonly used for ophthalmic treatments such as initiating mydriasis. Atropine displays cardiostimulatory/positive inotropic activity as well, increasing heart rate by inhibiting vagal nerve activity. In animal models of thermal pain, atropine exhibits analgesic activity; in other animal models, atropine inhibits histamine-induced increases in thromboxane A2 (TxA2) levels.

Product Info

Cas No.

5908-99-6
Purity

≥98%
Formula

(C17H23NO3)2 • H2SO4 • H2O
Formula Wt.

694.84
Chemical Name

α-(Hydroxymethyl)benzeneacetic acid (3-endo)-8- methyl-8-azabicyclo[3.2.1]oct-3-yl ester sulfate monohydrate
IUPAC Name

(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate;sulfuric acid;hydrate
Synonym

Atropine sulfate monohydrate, Atropisol, Atropt
Melting Point

190-194°C

Solubility

Soluble in water (2 g/mL),ethanol (200 mg/mL) chloroform (1g/420mL) or glycerol (400 mg/mL).
Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

A7672 MSDS PDF
Info Sheet

A7672 Info Sheet PDF

References

Ghelardini C, Malmberg-Aiello P, Giotti A, et al. Investigation into atropine-induced antinociception. Br J Pharmacol. 1990 Sep;101(1):49-54. PMID: 2282466.

Alberts P, Ogren VR. Interaction of forskolin with the effect of atropine on [3H]acetylcholine secretion in guinea-pig ileum myenteric plexus. J Physiol. 1988 Jan;395:441-53. PMID: 2457681.

Berti F, Folco GC, Giachetti A, et al. Atropine inhibits thromboxane A2 generation in isolated lungs of the guinea-pig. Br J Pharmacol. 1980 Mar;68(3):467-72. PMID: 7052339.

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