Prednisone Acetate

Product ID P7021

Cas No. 125-10-0

Purity ≥98%

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Product Info
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Description
Product Info
Shipping and Storage
Downloads
References
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Description

Prednisone is a synthetic corticosteroid/glucocorticoid that exhibits no biological activity until converted to its active metabolite, prednisolone. Once converted, this compound exhibits anti-inflammatory, immunosuppressive, anti-allergic, neuroprotective, and anticancer chemotherapeutic activities. Prednisone is one component of the CHOP chemotherapeutic cocktail that is clinically used to treat leukemias and lymphomas; in animal models of subarachnoid hemorrhage, CHOP inhibits neuronal apoptosis. Prednisone also inhibits expression of IL-6 and is clinically used to treat rheumatoid arthritis.

Product Info

Cas No.	125-10-0
Purity	≥98%
Formula	C₂₃H₂₈O₆
Formula Wt.	400.46
Chemical Name	17,21-Dihydroxypregna-1,4-diene-3,11,20-trione acetate
IUPAC Name	[2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-6,7,8, 9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
Synonym	Prednisone 21-acetate, Pred Forte
Melting Point	226-232°C (dec)
Solubility	Insoluble in water. Slightly soluble in ethanol.
Appearance	White or almost white Crystal Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	P7021 MSDS PDF
Info Sheet	P7021 Info Sheet PDF

References

Hoy SM. Bendamustine: a review of its use in the management of chronic lymphocytic leukaemia, rituximab-refractory indolent non-Hodgkin's lymphoma and multiple myeloma. Drugs. 2012 Oct 1;72(14):1929-50. PMID: 22950536.

Clarke L, Kirwan J. Efficacy, safety and mechanism of action of modified-release prednisone in rheumatoid arthritis. Ther Adv Musculoskelet Dis. 2012 Jun;4(3):159-66. PMID: 22850902.

He Z, Ostrowski RP, Sun X, et al. CHOP silencing reduces acute brain injury in the rat model of subarachnoid hemorrhage. Stroke. 2012 Feb;43(2):484-90. PMID: 22180248.

Manns MP, Strassburg CP. Therapeutic strategies for autoimmune hepatitis. Dig Dis. 2011;29(4):411-5. PMID: 21894012.