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Desmopressin is a synthetic peptide derivative of arginine vasopressin that binds and activates vasopressin-2 receptors (V2Rs). Desmopressin exhibits pro-coagulant/pro-thrombotic and antidiuretic activities and is clinically used to treat bleeding disorders such as hemophilia. Desmopressin enhances platelet pro-coagulant activity and increase platelet-dependent thrombin generation in a Na+/Ca2+-dependent manner.
| Cas No. | 16679-58-6 |
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| Purity | ≥95% |
| Formula | C46H64N14O12S2 |
| Formula Wt. | 1069.1 |
| Chemical Name | 1-(3-mercaptopropanoic acid)-8-D-arginine vasopressin |
| IUPAC Name | N-[1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1- oxopentan-2-yl]-1-[7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13- benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5, 8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide |
| Synonym | Minirin, Desmospray, Adiuretin SD. |
| Solubility | Soluble in DMSO (5 mg/mL), DMF, water (4 mg/mL). |
| Appearance | White to off-white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Colucci G, Stutz M, Rochat S, et al. The effect of desmopressin on platelet function: a selective enhancement of procoagulant COAT-platelets in patients with primary platelet function defects. Blood. 2014 Jan 17. [Epub ahead of print]. PMID: 24443440.
Leissinger C, Carcao M, Gill JC, et al. Desmopressin (DDAVP) in the management of patients with congenital bleeding disorders. Haemophilia. 2014 Mar;20(2):158-67. PMID: 23937614.
Juul KV, Klein BM, Sandström R, et al. Gender difference in antidiuretic response to desmopressin. Am J Physiol Renal Physiol. 2011 May;300(5):F1116-22. PMID: 21367921.
Slusarz MJ, Slusarz R, Ciarkowski J. Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system. Biopolymers. 2006 Apr 5;81(5):321-38. PMID: 16333859.
