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Desmopressin

Product ID D1776
Cas No. 16679-58-6
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $185.30 In stock
2 mg $315.20 In stock
5 mg $556.20 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Desmopressin is a synthetic peptide derivative of arginine vasopressin that binds and activates vasopressin-2 receptors (V2Rs). Desmopressin exhibits pro-coagulant/pro-thrombotic and antidiuretic activities and is clinically used to treat bleeding disorders such as hemophilia. Desmopressin enhances platelet pro-coagulant activity and increase platelet-dependent thrombin generation in a Na+/Ca2+-dependent manner.

Product Info

Cas No.

16679-58-6

Purity

≥95%

Formula

C46H64N14O12S2

Formula Wt.

1069.1

Chemical Name

1-(3-mercaptopropanoic acid)-8-D-arginine vasopressin

IUPAC Name

N-[1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1- oxopentan-2-yl]-1-[7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13- benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5, 8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide

Synonym

Minirin, Desmospray, Adiuretin SD.

Solubility

Soluble in DMSO (5 mg/mL), DMF, water (4 mg/mL).

Appearance

White to off-white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

D1776 MSDS PDF

Info Sheet

D1776 Info Sheet PDF

References

Colucci G, Stutz M, Rochat S, et al. The effect of desmopressin on platelet function: a selective enhancement of procoagulant COAT-platelets in patients with primary platelet function defects. Blood. 2014 Jan 17. [Epub ahead of print]. PMID: 24443440.

Leissinger C, Carcao M, Gill JC, et al. Desmopressin (DDAVP) in the management of patients with congenital bleeding disorders. Haemophilia. 2014 Mar;20(2):158-67. PMID: 23937614.

Juul KV, Klein BM, Sandström R, et al. Gender difference in antidiuretic response to desmopressin. Am J Physiol Renal Physiol. 2011 May;300(5):F1116-22. PMID: 21367921.

Slusarz MJ, Slusarz R, Ciarkowski J. Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system. Biopolymers. 2006 Apr 5;81(5):321-38. PMID: 16333859.

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