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Apremilast

Apremilast

Product ID A6269
Cas No. 608141-41-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $81.90 In stock
5 mg $220.50 In stock
25 mg $630.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Apremilast is an inhibitor of phosphodiesterase 4 (PDE4) that is clinically used to treat psoriasis and psoriatic arthritis. Apremilast exhibits anti-inflammatory and immunomodulatory activities, increasing levels of cAMP and IL-10 and decreasing levels of iNOS, IL-23, and TNF-α in vitro and in vivo. An analog of thalidomide.

Product Info

Cas No.

608141-41-9

Purity

≥98%

Formula

C23H25N2O7S

Formula Wt.

460.51

IUPAC Name

N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-1,3-dioxoisoindol-4-yl]acetamide

Synonym

CC-10004; CC10004

Melting Point

156.1°C

Solubility

Insoluble in water. Slightly soluble in ethanol. Soluble in acetone (20mg/mL), DMSO (80 mg/mL).

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A6269 MSDS PDF

Info Sheet

A6269 Info Sheet PDF

References

Schafer PH, Parton A, Capone L, et al. Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity. Cell Signal. 2014 Sep;26(9):2016-29. PMID: 24882690.

Schafer P. Apremilast mechanism of action and application to psoriasis and psoriatic arthritis. Biochem Pharmacol. 2012 Jun 15;83(12):1583-90. PMID: 22257911.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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