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Carfilzomib

Carfilzomib

Product ID C0271
Cas No. 868540-17-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $105.30 In stock
5 mg $202.90 In stock
25 mg $593.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Carfilzomib is an analog of epoxomicin that functions as a proteasome inhibitor. This drug has been approved for use in humans with multiple myeloma. Carfilzomib binds irreversibly to the 20S proteasome, which exhibits chymotrypsin-like activity and is responsible for degradation of cellular proteins; as a result, concentrations of polyubiquitinated proteins build up, inducing cell cycle arrest at the G2/M phase, apoptosis, and decreased tumor growth.

Product Info

Cas No.

868540-17-4

Purity

≥98%

Formula

C40H57N5O7

Formula Wt.

719.91

Chemical Name

(2S)-4-methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1- oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2- morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide

IUPAC Name

(2S)-4-methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1- oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2- morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide

Synonym

PR-171

Solubility

The solubility of carfilzomib in ethanol is approximately 1 mg/ml and approximately 15 mg/ml in DMSO and DMF. Carfilzomib is sparingly soluble in aqueous solutions.

Appearance

white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

C0271 MSDS PDF

Info Sheet

C0271 Info Sheet PDF

References

Gu JJ, Hernandez-Ilizaliturri FJ, Kaufman GP, et al. The novel proteasome inhibitor carfilzomib induces cell cycle arrest, apoptosis and potentiates the anti-tumour activity of chemotherapy in rituximab-resistant lymphoma. Br J Haematol. 2013 Jul 4. Epub ahead of print] PMID: 23826755.

Lee HC, Shah JJ, Orlowski RZ. Novel approaches to treatment of double-refractory multiple myeloma. Am Soc Clin Oncol Educ Book. 2013;2013:302-6. doi: E10.1200/EdBook_AM.2013.33.e302. PMID: 23714530.

Nooka A, Gleason C, Casbourne D, et al. Relapsed and refractory lymphoid neoplasms and multiple myeloma with a focus on carfilzomib. Biologics. 2013;7:13-32. PMID: 23386784

Custom Order

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