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OTX-015

OTX-015

Product ID O7992
Cas No. 202590-98-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $97.30 In stock
5 mg $194.70 In stock
10 mg $324.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

OTX-015 (Birabresib) is an inhibitor of bromodomains (BRD) proteins such as BRD2/3/4; it is currently in clinical trials as a potential treatment for leukemias and other cancers. OTX-015 displays anticancer chemotherapeutic activity, inhibiting cell growth and tumor growth in various animal models, including anaplastic large cell lymphoma. This compound also induces apoptosis in activated B-cell-like diffuse large B-cell lymphoma cells.

Product Info

Cas No.

202590-98-5

Purity

≥98%

Formula

C25H22ClN5O2S

Formula Wt.

491.99

IUPAC Name

2-[(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-(4-hydroxyphenyl)acetamide

Synonym

OTX015; Y-803; Birabresib; MK-8626; MK8628

Solubility

DMSO: ≥ 49 mg/mL

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

O7992 MSDS PDF

Info Sheet

O7992 Info Sheet PDF

References

Boi M, Gaudio E, Bonetti P, et al. The BET Bromodomain Inhibitor OTX015 Affects Pathogenetic Pathways in Preclinical B-cell Tumor Models and Synergizes with Targeted Drugs. Clin Cancer Res. 2015 Apr 1;21(7):1628-38.PMID: 25633213.

Noel JK, Iwata K, Ooike S, et al. Development of the BET bromodomains inhibitor OTX015. Mol Cancer Ther. 2013 Nov:12;C244.

Boi M, Todaro M, Vurchio V, et al. OTX015, a bromodomains and extraterminal inhibitor, represents a novel agent for ALK positive anaplastic large cell lymphoma. Mol Cancer Ther. 2013 Nov:12;A219.

Custom Order

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