Name: GSK-343
SKU: G7442
Availability: InStock

Description

GSK-343 is an inhibitor of enhancer of zeste homolog 2 (EZH2) histone methyltransferase (HMT). GSK-343 exhibits anticancer activity, inhibiting cell invasion and cell growth in epithelial ovarian cancer cells.

Product Info

Cas No.	1346704-33-3
Purity	≥98%
Formula	C₃₁H₃₉N₇O₂
Formula Wt.	541.69
IUPAC Name	N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-1-propan-2-ylindazole-4-carboxamide
Solubility	Ethanol (2 mg/ml), DMSO (15 mg/ml), DMF (25 mg/ml)
Appearance	Light Gray Powder

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	G7442 MSDS PDF
Info Sheet	G7442 Info Sheet PDF
Brochures	Epigenetic Modifiers Booklet

References

Amatangelo MD, Garipov A, Li H, et al. Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition. Cell Cycle. 2013 Jul 1;12(13):2113-9. PMID: 23759589.

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GSK-343

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