LKT Labs

Biochemicals for Life Science Research

Theaflavin-3,3’-digallate

Product ID T286163
Cas No. 30462-35-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $184.00 In stock
5 mg $681.50 In stock
Bulk Quote

Quicklinks

Description

Theaflavin-3,3’-digallate is a polyphenolic compound found in black tea. The theaflavins are formed during the enzymatic oxidation of catechins, which happens during processing of the fresh tea leaves. Theaflavin-3,3’-digallate has also shown inhibitory effects on ovarian cancer cells OVCAR-3 and A2780/CP70 by inducing apoptosis and impairing tumor angiogenesis. In addition, theaflavin-3,3’-digallate was found to produce notably efficient reactive oxygen species scavenging activity by a chemiluminescence assay. Theaflavin-3,3’-digallate was also shown to produce chemopreventive effects through the inhibition of the EGFR signaling pathway as a result of EGFR down-regulation.

Product Info

Cas No.

30462-35-2
Purity

≥98%
Formula

C43H32O20
Formula Wt.

868.71
Chemical Name

[(2R,3R)-2-[1-[(2R,3R)-5,7-Dihydroxy-3-(3,4,5-trihydroxybenzoyl)oxy-3,4-dihydro-2H-chromen-2-yl]-3,4,5-trihydroxy-6-oxobenzo[7]annulen-8-yl]-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate
IUPAC Name

(3,4,5-Trihydroxy-6-oxo-6H-benzo[7]annulene-1,8-diyl)bis[(2R,3R)-5,7-dihydroxy-3,4-dihydro-2H-chromene-2,3-diyl] bis(3,4,5-trihydroxybenzoate)
Synonym

Theaflavin digallate
Melting Point

226-230°C dec
Solubility

0.1 mg/mL water.
Appearance

Brick red powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

T286163 MSDS PDF
Info Sheet

T286163 Info Sheet PDF

References

Gao Y, Rankin GO, Tu Y, et al. Inhibitory effects of the four main theaflavin derivatives found in black tea on ovarian cancer cells. Anticancer Res. 2016 Feb;36(2):643-651. PMID: 26851019.

Wu YY, Li W, Xu Y, et al. Evaluation of the antioxidant effects of four main theaflavin derivatives through chemiluminescence adn DNA damage analyses. J Zhejiang Univ Sci B. 2011 Sep;12(9):744-751. PMID: 21887850.

Mizuno H, Cho YY, Zhu F, et al. Theaflavin-3,-3’-digallate induces epidermal growth factor receptor downregulation. Mol Carcinog. 2006 Mar;45(3):204-212. PMID: 16353237.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.