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Tobramycin, Free Base

Product ID T5604
Cas No. 32986-56-4
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $62.50 In stock
100 mg $94.30 In stock
500 mg $288.90 In stock
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  • Product Info
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  • Description
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Description

Tobramycin is an aminoglycoside antibiotic that exhibits antibacterial and anti-inflammatory activities. Tobramycin prevents formation of the 70S bacterial ribosomal complex, inhibiting protein translation; it is highly effective in the treatment of Pseudomonas infections. In vitro, tobramycin inhibits T cell and neutrophil migration. In separate cellular models, this compound also decreases activation of NF-κB, expression of MUC5AC, and phosphorylation of ERK and p38 MAPK.

Product Info

Cas No.

32986-56-4

Purity

≥98%

Formula

C18H37N5O9

Formula Wt.

467.51

Chemical Name

O-3-Amino-3-deoxy-α-d-glucopyranosyl-(1->6)-O- [2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl- (1->4)]-2-deoxy-D-streptamine

IUPAC Name

(2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S, 6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl] oxy-6-(hydroxymethyl)oxane-3,5-diol

Synonym

Nebramycin factor 6, NF 6, Tobracin, Tobralex, Tobramaxin, Tobrex

Melting Point

178°C

Solubility

Soluble in water. Slightly soluble in ethanol. Practically insoluble in ether or chloroform.

Appearance

White to off-white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T5604 MSDS PDF

Info Sheet

T5604 Info Sheet PDF

References

Papich MG. Antibiotic treatment of resistant infections in small animals. Vet Clin North Am Small Anim Pract. 2013 Sep;43(5):1091-107. PMID: 23890241.

Gziut M, MacGregor HJ, Nevell TG, et al. Anti-inflammatory effects of tobramycin and a copper-tobramycin complex with superoxide dismutase-like activity. Br J Pharmacol. 2013 Mar;168(5):1165-81. PMID: 23072509.

Nakamura S, Yanagihara K, Araki N, et al. High-dose tobramycin inhibits lipopolysaccharide-induced MUC5AC production in human lung epithelial cells. Eur J Pharmacol. 2011 Mar 21. [Epub ahead of print]. PMID: 21414310.

Periti P. Tobramycin--clinical pharmacology and chemotherapy. J Chemother. 1996 Jan;8 Suppl 1:3-30. PMID: 8948764.

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