I-BET-762

Name: I-BET-762
SKU: I0518
Availability: InStock

Product ID I0518

Cas No. 1260907-17-2

Purity ≥98%

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Description

I-BET-762 is a BET bromodomain (BRD) inhibitor that prevents association of BRDs with chromatin histones; it exhibits immunosuppressive, anticancer, and anti-inflammatory activities. In animal models of experimental autoimmune encephalitis (EAE), I-BET-762 decreases production of pro-inflammatory cytokines, increases production of anti-inflammatory cytokines, and prevents antigen-specific T cell induction of pathogenesis. This compound also inhibits proliferation of B-cell acute lymphoblastic leukemia cells.

Product Info

Cas No.	1260907-17-2
Purity	≥98%
Formula	C₂₂H₂₂ClN₅O₂
Formula Wt.	423.90
IUPAC Name	2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide
Synonym	GSK525762
Solubility	DMSO 84 mg/mL (198.15 mM) Ethanol 42 mg/mL warmed (99.07 mM) Water Insoluble
Appearance	Off white (Beige) Powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	I0518 MSDS PDF
Info Sheet	I0518 Info Sheet PDF

References

Ma S, Chen C, Zhu J, et al. In vitro study of BRD4 inhibitor GSK525762A against primary adult common B-cell acute lymphoblastic leukemia cells in vitro. Zhonghua Xue Ye Xue Za Zhi. 2015 Jul 14;36(7):563-9. PMID: 26304078.

Bandukwala HS, Gagnon J, Togher S, et al. Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14532-7. PMID: 22912406.