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Riluzole

Product ID R3347
Cas No. 1744-22-5
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $97.30 In stock
250 mg $730.00 In stock
500 mg $1,168.30 In stock
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Description

Riluzole is clinically used to treat symptoms of amyotrophic lateral sclerosis (ALS). Riluzole inhibits Na+, K+, and Ca2+ currents and may display anticonvulsant activity, inhibiting rhythmic motor disorders. Riluzole also exhibits antinociceptive, anxiolytic, and anti-parasitic activities. Riluzole reverses cutaneous hypersensitivity in animal models of thermal pain, increasing response latency. This compound also improves performance of animals in the elevated plus maze, light/dark avoidance test, and open field test. Additionally, riluzole activates transient receptor potential canonical 5 (TRPC5) channels. Riluzole inhibits pteridine reductase 1 (PTR1) in parasites, increasing oxidative stress and resulting in death of Leishmania parasites. In vitro, riluzole increases glucose transport and upregulates translocation of glucose transporters to the plasma membrane. Riluzole may be a non-competitive inhibitor of kainate receptors and NMDA receptors.

Product Info

Cas No.

1744-22-5

Purity

≥98%

Formula

C8H5F3N2OS

Formula Wt.

234.19

Chemical Name

6-(trifluoromethoxy)-1,3-benzothiazol-2-amine

IUPAC Name

6-(trifluoromethoxy)-1,3-benzothiazol-2-amine

Synonym

Rilutek

Melting Point

119°C

Appearance

White Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

R3347 MSDS PDF

Info Sheet

R3347 Info Sheet PDF

Brochures

TRP Channel Modulator Flyer

References

Richter JM, Schaefer M, Hill K. Riluzole activates TRPC5 channels independently of PLC activity. Br J Pharmacol. 2014 Jan;171(1):158-70. PMID: 24117252.

Daniel B, Green O, Viskind O, et al. Riluzole increases the rate of glucose transport in L6 myotubes and NSC-34 motor neuron-like cells via AMPK pathway activation. Amyotroph Lateral Scler Frontotemporal Degener. 2013 Sep;14(5-6):434-43. PMID: 23834207.

Guerrieri D, Ferrari S, Costi MP, et al. Biochemical effects of riluzole on Leishmania parasites. Exp Parasitol. 2013 Mar;133(3):250-4. PMID: 23206955.

Sugiyama A, Saitoh A, Iwai T, et al. Riluzole produces distinct anxiolytic-like effects in rats without the adverse effects associated with benzodiazepines. Neuropharmacology. 2012 Jun;62(8):2489-98. PMID: 22377384.

Bellingham MC. A review of the neural mechanisms of action and clinical efficiency of riluzole in treating amyotrophic lateral sclerosis: what have we learned in the last decade? CNS Neurosci Ther. 2011 Feb;17(1):4-31. PMID: 20236142.

Hama A, Sagen J. Antinociceptive effect of riluzole in rats with neuropathic spinal cord injury pain. J Neurotrauma. 2011 Jan;28(1):127-34. PMID: 20954888.

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