• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Riluzole

Riluzole

Product ID R3347
Cas No. 1744-22-5
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $77.70 In stock
250 mg $567.00 In stock
500 mg $987.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Riluzole is clinically used to treat symptoms of amyotrophic lateral sclerosis (ALS). Riluzole inhibits Na+, K+, and Ca2+ currents and may display anticonvulsant activity, inhibiting rhythmic motor disorders. Riluzole also exhibits antinociceptive, anxiolytic, and anti-parasitic activities. Riluzole reverses cutaneous hypersensitivity in animal models of thermal pain, increasing response latency. This compound also improves performance of animals in the elevated plus maze, light/dark avoidance test, and open field test. Additionally, riluzole activates transient receptor potential canonical 5 (TRPC5) channels. Riluzole inhibits pteridine reductase 1 (PTR1) in parasites, increasing oxidative stress and resulting in death of Leishmania parasites. In vitro, riluzole increases glucose transport and upregulates translocation of glucose transporters to the plasma membrane. Riluzole may be a non-competitive inhibitor of kainate receptors and NMDA receptors.

Product Info

Cas No.

1744-22-5

Purity

≥98%

Formula

C8H5F3N2OS

Formula Wt.

234.19

Chemical Name

6-(trifluoromethoxy)-1,3-benzothiazol-2-amine

IUPAC Name

6-(trifluoromethoxy)-1,3-benzothiazol-2-amine

Synonym

Rilutek

Melting Point

119°C

Appearance

White Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

R3347 MSDS PDF

Info Sheet

R3347 Info Sheet PDF

Brochures

TRP Channel Modulator Flyer

References

Richter JM, Schaefer M, Hill K. Riluzole activates TRPC5 channels independently of PLC activity. Br J Pharmacol. 2014 Jan;171(1):158-70. PMID: 24117252.

Daniel B, Green O, Viskind O, et al. Riluzole increases the rate of glucose transport in L6 myotubes and NSC-34 motor neuron-like cells via AMPK pathway activation. Amyotroph Lateral Scler Frontotemporal Degener. 2013 Sep;14(5-6):434-43. PMID: 23834207.

Guerrieri D, Ferrari S, Costi MP, et al. Biochemical effects of riluzole on Leishmania parasites. Exp Parasitol. 2013 Mar;133(3):250-4. PMID: 23206955.

Sugiyama A, Saitoh A, Iwai T, et al. Riluzole produces distinct anxiolytic-like effects in rats without the adverse effects associated with benzodiazepines. Neuropharmacology. 2012 Jun;62(8):2489-98. PMID: 22377384.

Bellingham MC. A review of the neural mechanisms of action and clinical efficiency of riluzole in treating amyotrophic lateral sclerosis: what have we learned in the last decade? CNS Neurosci Ther. 2011 Feb;17(1):4-31. PMID: 20236142.

Hama A, Sagen J. Antinociceptive effect of riluzole in rats with neuropathic spinal cord injury pain. J Neurotrauma. 2011 Jan;28(1):127-34. PMID: 20954888.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S584778

    Sotorasib

    KRAS inhibitor

    ≥99%
  • F4532

    Flibanserin

    5-HT1A agonist, 5-HT2A antagonist.

    ≥97%
  • S3568

    Siramesine

    σ2 agonist.

    ≥98%
  • C1844

    Celastrol

    Triterpene isolated Trypterigium wilfordii; HSP...

    ≥98%
  • K5604

    Kobe 0065

    Ras inhibitor.

    ≥99%
  • C1649

    β-Cembrenediol

    Diterpene found in Anisomeles.

    ≥99%
  • B030966

    BAY 11-7082

    inhibits inflammatory signaling

    ≥98%
  • R0250

    Ranatensin

    Peptide found in amphibians.

    ≥98%
  • N1744

    Nelarabine

    Nucleoside (guanosine) analog; DNA chain termin...

    ≥98%
  • P8167

    Puromycin Aminonucleoside

    Purine nucleoside analog; DNA chain terminator,...

    ≥98%
  • A9914

    AZD-8055

    mTOR inhibitor.

    ≥98%
  • P6959

    Prothionamide

    Nicotinic acid derivative; InhA inhibitor.

    ≥98%
  • A7657

    Atosiban Acetate

    Peptide, alters uterine contractility; V1/2 and...

    ≥95%
  • N0263

    Naphazoline Nitrate

    α1-adrenergic agonist.

    ≥97%
  • T1654

    Tenoxicam

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • D0260

    DAPT

    γ-Secretase inhibitor.

    ≥98%
  • C5870

    Corosolic Acid

    Pentacyclic triterpene found in the Banaba plan...

    ≥98%
  • M1680

    5-Methoxyindole

    Core structure of melatonin; potential PPARγ a...

    ≥98%
  • D1621

    Deferasirox

    Iron chelator.

    ≥99%
  • A6934

    Aristolochic Acid C

    Found in Aristolochia and Radix; potential PLA2...

    ≥94%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only