• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Riluzole

Riluzole

Product ID R3347
Cas No. 1744-22-5
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $77.70 In stock
250 mg $567.00 In stock
500 mg $987.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Riluzole is clinically used to treat symptoms of amyotrophic lateral sclerosis (ALS). Riluzole inhibits Na+, K+, and Ca2+ currents and may display anticonvulsant activity, inhibiting rhythmic motor disorders. Riluzole also exhibits antinociceptive, anxiolytic, and anti-parasitic activities. Riluzole reverses cutaneous hypersensitivity in animal models of thermal pain, increasing response latency. This compound also improves performance of animals in the elevated plus maze, light/dark avoidance test, and open field test. Additionally, riluzole activates transient receptor potential canonical 5 (TRPC5) channels. Riluzole inhibits pteridine reductase 1 (PTR1) in parasites, increasing oxidative stress and resulting in death of Leishmania parasites. In vitro, riluzole increases glucose transport and upregulates translocation of glucose transporters to the plasma membrane. Riluzole may be a non-competitive inhibitor of kainate receptors and NMDA receptors.

Product Info

Cas No.

1744-22-5

Purity

≥98%

Formula

C8H5F3N2OS

Formula Wt.

234.19

Chemical Name

6-(trifluoromethoxy)-1,3-benzothiazol-2-amine

IUPAC Name

6-(trifluoromethoxy)-1,3-benzothiazol-2-amine

Synonym

Rilutek

Melting Point

119°C

Appearance

White Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

R3347 MSDS PDF

Info Sheet

R3347 Info Sheet PDF

Brochures

TRP Channel Modulator Flyer

References

Richter JM, Schaefer M, Hill K. Riluzole activates TRPC5 channels independently of PLC activity. Br J Pharmacol. 2014 Jan;171(1):158-70. PMID: 24117252.

Daniel B, Green O, Viskind O, et al. Riluzole increases the rate of glucose transport in L6 myotubes and NSC-34 motor neuron-like cells via AMPK pathway activation. Amyotroph Lateral Scler Frontotemporal Degener. 2013 Sep;14(5-6):434-43. PMID: 23834207.

Guerrieri D, Ferrari S, Costi MP, et al. Biochemical effects of riluzole on Leishmania parasites. Exp Parasitol. 2013 Mar;133(3):250-4. PMID: 23206955.

Sugiyama A, Saitoh A, Iwai T, et al. Riluzole produces distinct anxiolytic-like effects in rats without the adverse effects associated with benzodiazepines. Neuropharmacology. 2012 Jun;62(8):2489-98. PMID: 22377384.

Bellingham MC. A review of the neural mechanisms of action and clinical efficiency of riluzole in treating amyotrophic lateral sclerosis: what have we learned in the last decade? CNS Neurosci Ther. 2011 Feb;17(1):4-31. PMID: 20236142.

Hama A, Sagen J. Antinociceptive effect of riluzole in rats with neuropathic spinal cord injury pain. J Neurotrauma. 2011 Jan;28(1):127-34. PMID: 20954888.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A985120

    AZD-0156

    Inhibitor of ATM.

    ≥98%
  • O1200

    Odanacatib

    Cathepsin K inhibitor.

    ≥99%
  • G0250

    cGAMP Disodium [STING Ligand]

    Cyclic dinucleotide that detects cytosolic DNA ...

    ≥98%
  • N8662

    NVP-BGJ398

    FGFR inhibitor.

    ≥98%
  • V3325

    Virginiamycin M1

    Macrolide antibiotic; peptidyl transferase inhi...

    ≥97%
  • P7082

    Prulifloxacin

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • I0418

    Iberverin

    ITC found in cruciferous vegetables, homolog of...

    ≥98%
  • V182685

    Verdinexor

    CRM1/XPO1 inhibitor.

    ≥99%
  • L1044

    LCL-161

    SMAC mimetic; PXR agonist, IAP inhibitor.

    ≥99%, ≥99%ee, de
  • L8010

    D-Luciferin Potassium

    Heterocyclic light-emitting compound, natural l...

    ≥98%
  • P3568

    Pirarubicin

    Anthracycline, DNA intercalator; topoisomerase ...

    ≥98%
  • M4652

    MLN8237

    AurKA inhibitor.

    ≥98%
  • G1849

    Gemifloxacin Mesylate

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • M002698

    M2698

    Dual inhibitor of p70S6K and Akt.

    ≥99%
  • G0246

    Galantamine Hydrobromide

    Alkaloid found in Galanthus, Narcissus, Leucoju...

    ≥98%
  • A5326

    Aniracetam

    AMPA positive allosteric modulator, D2, 5-HT2A,...

    ≥98%
  • S0254

    Sanguinarine Chloride

    Decreases expression of MMPs, PGE2, and COX-2, ...

    ≥98%
  • S8046

    R-Sulforaphane, High Purity

    Naturally occuring isothiocyanate found in broc...

    ≥98%
  • L920000

    LX-2343

    Promotes Aβ clearance.

    ≥98%
  • D0004

    Dabrafenib

    B-Raf and c-Raf inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only