LKT Labs

Biochemicals for Life Science Research

BAY 11-7082

BAY 11-7082

Product ID B030966
Cas No. 19542-67-7
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $60.10 In stock
10 mg $90.30 In stock
25 mg $165.40 In stock
100 mg $450.80 In stock
Bulk Quote

Quicklinks

Description

BAY 11-7082 is an inhibitor of IkappaBalpha phosphorylation and degradation. Treatment of multiple myeloma cells with BAY 11-7082 has been shown to induce rapid swelling followed by disintegration of the cell body. Studies have shown that BAY 11-7082 inhibits not only NF-kB, but in addition inhibits many components of inflammatory signaling pathways including PI3K/Akt/IKK/NFkB, ERK/JNK/AP-1, TBK1/IRF-3, and Jak-2/STAT-1. BAY 11-7082 has also been found to target the NLRP3 inflammasome pathway at many levels.

Product Info

Cas No.

19542-67-7
Purity

≥98%
Formula

C10H9NO2S
Formula Wt.

207.25
Chemical Name

3-[(4-methylphenyl)sulfonyl]-(2E)-propenenitrile
IUPAC Name

(2E)-3-[(4-Methylphenyl)sulfonyl]acrylonitrile
Synonym

(E)-3-(p-Toluenesulfonyl)acrylonitrile
Solubility

Soluble in DMSO (>25 mg/ml), ethanol (15 mg/ml), methanol, dichloromethane, DMF (~25 mg/ml), and 1:3 DMF:PBS (pH 7.2) (~0.25 mg/ml). Insoluble in water, and sparingly soluble in aqueous buffers.
Appearance

White poweder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

B030966 MSDS PDF
Info Sheet

B030966 Info Sheet PDF

References

Goffi F, Boroni F, Benarese M, et al. The inhibitor of I kappa B alpha phosphorylation BAY 11-7082 prevents NMDA neurotoxicity in mouse hippocampal slices. Neurosci Lett. 2005 Apr 4;377(3):147-151. PMID: 15755516.

Rauert-Wunderlich H, Siegmund D, Maier E, et al. The IKK inhibitor BAY 11-7082 induces cell death independent from inhibition of activation of NFkB transcription factors. PLoS One. 2013;8(3):e59292. PMID: 23527154.

Strickson S, Campbell DG, Emmerich CH, et al. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signaling network by targeting the ubiquitin system. Biochem J. 2013 May 1;451(3):427-437. PMID: 23441730.

Lee J, Rhee MH, Kim E, et al. BAY 11-7082 is a broad-spectrum inhibitor with anti-inflammatory activity against multiple targets. Mediators Inflamm. 2012;2012:416036. PMID: 27745523.

Juliana C, Fernandes-Alnemri T, Wu J, et al. Anti-inflammatory compounds parthenolide and BAY 11-7082 are direct inhibitors of the inflammasome. J Biol Chem. 2010 Mar 26;285(13):9792-9802. PMID: 20093358.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C9608

    Cycloastragenol

    Triterpene aglycone found in Radix Astragali; t...

    ≥98%
  • A0964

    Adrenocorticotropic Hormone (1-13), human

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • O1179

    n-Octyl-4-methylcaffeate

    Derivative of methyl caffeate, hydroxycinnamic ...

    ≥98%
  • B1545

    Benzalkonium Bromide

    Quaternary ammonium cationic surfactant, dissoc...

    ≥95%
  • I7459

    1-Isothiocyanato-8-(methylsulfinyl)-octane

    ITC found in Nasturtium officinale (watercress)...

    ≥98%
  • A4646

    ALLN

    Calpain I/II inhibitor.

    ≥98%
  • S5722

    Sofosbuvir

    Viral RNA polymerase inhibitor.

    ≥98%
  • I7341

    Isoniazid

    Nicotinic acid derivative; InhA inhibitor.

    ≥98%
  • N8460

    NVP-BHG712

    EphB4 inhibitor.

    ≥98%
  • T2835

    6-Thioguanine

    Nucleotide (guanine) analog, prevents guanine s...

    ≥90%
  • R0247

    Raltegravir

    HIV integrase inhibitor.

    ≥99%
  • V0147

    Valproic Acid Sodium

    T-type Ca2+ and voltage-gated Na+ channel block...

    ≥98%
  • A4000

    AK-1

    SIRT2 inhibitor.

    ≥99%
  • E6825

    Ergosterol

    Sterol cell membrane component found in yeast a...

    ≥96%
  • F5773

    Fosinopril Sodium

    ACE inhibitor.

    ≥98%
  • C4657

    Clotrimazole

    Imidazole; 14-α demethylase, H+/K+ ATPase, Na+...

    ≥97%
  • S0254

    Sanguinarine Chloride

    Decreases expression of MMPs, PGE2, and COX-2, ...

    ≥98%
  • M184790

    Metyrapone

    Steroidogenesis inhibitor

    ≥98%
  • T3585

    Tivozanib

    VEGFR1/2/3, c-Kit, PDGFR inhibitor.

    ≥98%
  • E6235

    Epirubicin Hydrochloride

    Anthracycline, DNA intercalator; topoisomerase ...

    ≥90%