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Ropinirole is an indoline agonist at D2/3 receptors that is clinically used to treat restless leg syndrome and Parkinson’s disease. Ropinirole prevents dopaminergic neuron damage and MPTP-induced changes in motor coordination and balance in animal models, exhibiting neuroprotective benefit. Ropinirole also displays antidepressant activity, decreasing immobility time in the forced swim test.
| Cas No. | 91374-20-8 |
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| Purity | ≥99% |
| Formula | C16H24N2O • HCl |
| Formula Wt. | 296.84 |
| Chemical Name | 4-[2-(Dipropylamino)-ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride |
| IUPAC Name | 4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one;hydrochloride |
| Synonym | SKF-101468A |
| Melting Point | 241-243°C |
| Solubility | Soluble in water. |
| Appearance | Light Yellow Powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Park G, Park YJ, Yang HO, et al. Ropinirole protects against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced neurotoxicity in mice via anti-apoptotic mechanism. Pharmacol Biochem Behav. 2013 Mar;104:163-8. PMID: 23369986.
Ferini-Strambi L. Treatment options for restless legs syndrome. Expert Opin Pharmacother. 2009 Mar;10(4):545-54. PMID: 19284359.
Dhir A, Kulkarni SK. Involvement of dopamine (DA)/serotonin (5-HT)/sigma (sigma) receptor modulation in mediating the antidepressant action of ropinirole hydrochloride, a D2/D3 dopamine receptor agonist. Brain Res Bull. 2007 Sep 14;74(1-3):58-65. PMID: 17683790.
