LKT Labs

Biochemicals for Life Science Research

Okadaic Acid Sodium

Product ID O4104
Cas No. 209266-80-8
Purity ≥98%
Product Unit SizeCostQuantityStock
25 µg $197.70 In stock
100 µg $294.30 In stock
1 mg $1,471.50 Please Inquire
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Description

Okadaic acid is a diarrhetic shellfish toxin initially produced by dinoflagellates and sea sponges; it exhibits neurotoxic and anticancer activities. Okadaic acid inhibits protein phosphatases 1 and 2A (PP1, PP2A). In animal models of Alzheimer’s disease, okadaic acid increases phosphorylation of tau protein. In adipocytes, this compound stimulates lipolysis by increasing phosphorylation of perilipin A and B. In T cell leukemia cells, okadaic acid induces G1 phase cell cycle arrest, decreases expression of cyclin D2, CDK4, CDK6, Bcl-2, Bcl-xl, and XIAP, increases expression of p21 and p27, activates caspases, and inhibits cell growth.

Product Info

Cas No.

209266-80-8
Purity

≥98%
Formula

C44H67O13Na
Formula Wt.

827.0
Chemical Name

9,10-Deepithio-9,10-didehydroacanthifolicin sodium salt
Melting Point

164-166°C
Solubility

Soluble in ethanol, DMSO, or water.

Appearance

White crystal solid or clear colorless solid film

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

O4104 MSDS PDF
Info Sheet

O4104 Info Sheet PDF

References

Hendrickson O, Mukhametova L, Zvereva E, et al. A sensitive fluorescence polarization immunoassay for the rapid detection of okadaic acid in environmental waters. Biosensors (Basel). 2023 Apr 16;13(4):477. PMID: 37185552.

Kamat PK, Rai S, Swarnkar S, et al. Molecular and Cellular Mechanism of Okadaic Acid (OKA)-Induced Neurotoxicity: A Novel Tool for Alzheimer's Disease Therapeutic Application. Mol Neurobiol. 2014 Apr 8. [Epub ahead of print]. PMID: 24710687.

Chang NC, Lin AC, Hsu CC, et al. Okadaic Acid, a Bioactive Fatty Acid from Halichondria okadai, Stimulates Lipolysis in Rat Adipocytes: The Pivotal Role of Perilipin Translocation. Evid Based Complement Alternat Med. 2013;2013:545739. PMID: 24319476.

Mori N, Ishikawa C, Uchihara JN, et al. Protein phosphatase 2A as a potential target for treatment of adult T cell leukemia. Curr Cancer Drug Targets. 2013 Oct;13(8):829-42. PMID: 24015987.

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