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trans-Anethole

trans-Anethole

Product ID A5217
Cas No. 4180-23-8
Purity ≥98%
Product Unit SizeCostQuantityStock
50 ml $89.30 In stock
100 ml $183.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Trans-anethole is a phenylpropene derivative found in many essential oils, including anise oil. Trans-anethole is commercially used as an insecticide and flavorant. This compound exhibits neuromodulatory, anxiolytic, antioxidative, antifungal, anti-inflammatory, and immunomodulatory activities. Trans-anethole activates NMDA receptors, decreasing Ca2+ overload and ROS levels and protecting against cerebral ischemia-induced neurodegeneration. Trans-anethole also inhibits growth of Aspergillus and Saccharomyces. In vivo, this compound decreases expression of TNF-α, IL-6, HMGB-1, toll-like receptor 4 (TLR4), and MyD88 and suppresses activation of ERK, p38 MAPK, JNK, c-Jun, and NF-κB.

Product Info

Cas No.

4180-23-8

Purity

≥98%

Formula

C10H12O

Formula Wt.

148.20

Chemical Name

1-Methoxy-4-(1E)-1-propenylbenzene

IUPAC Name

1-methoxy-4-[(E)-prop-1-enyl]benzene

Synonym

trans-p-Propenylanisole, Anise camphor, Isoestragole, Monasirup

Melting Point

21.4°C

Solubility

Soluble in benzene, ethyl acetate, acetone, carbon disulfide, petroleum ether, ethanol (500 mg/mL).

Appearance

Colorless Liquid

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A5217 MSDS PDF

Info Sheet

A5217 Info Sheet PDF

References

Miyagawa M, Satou T, Yukimune C, et al. Anxiolytic-Like Effect of Illicium verum Fruit Oil, trans-Anethole and Related Compounds in Mice. Phytother Res. 2014 Jun 11. [Epub ahead of print]. PMID: 24919985.

Ryu S, Seol GH, Park H, et al. Trans-anethole protects cortical neuronal cells against oxygen-glucose deprivation/reoxygenation. Neurol Sci. 2014 Oct;35(10):1541-7. PMID: 24777545.

Fujita KI, Tatsumi M, Ogita A, et al. Anethole induces apoptotic cell death accompanied by reactive oxygen species production and DNA fragmentation in Aspergillus fumigatus and Saccharomyces cerevisiae. FEBS J. 2014 Jan 2. [Epub ahead of print]. PMID: 24393541.

Cho HI, Kim KM, Kwak JH, et al. Protective mechanism of anethole on hepatic ischemia/reperfusion injury in mice. J Nat Prod. 2013 Sep 27;76(9):1717-23. PMID: 23962021.

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