• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Genistein

Genistein

Product ID G1652
Cas No. 446-72-0
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $64.90 In stock
500 mg $114.60 In stock
1 g $214.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Genistein is an isoflavone and phytoestrogen that was originally found in Genista but has since been found in many other plant sources, including soy. Genistein exhibits anti-resorptive, anti-osteoporotic, antioxidative, anti-obesity, anti-diabetic, anti-hyperlipidemic, neuroprotective, anti-inflammatory, anticancer, and anti-metastatic activities. Genistein inhibits osteoclast formation in macrophages and induces phase II enzymes such as superoxide dismutase, heme oxygenase 1 (HO-1) and Nrf2 in other cellular models. In high fat diet fed animal models, genistein decreases body weight, liver weight, lipid levels, and insulin dysregulation by inhibiting S6K1 signaling. In animal models of cerebral occlusion, genistein decreases infarct volume and neuronal apoptosis, increases activation of ERK1/2, and improves neurological and survival outcomes. In cellular models of Alzheimer’s disease, genistein increases PKC signaling and inhibits amyloid-β (Aβ)-induced neurotoxicity. In other cellular models, this compound decreases activation of NF-κB and expression of IL-1β, IL-6, and IL-8 in an AMPK-dependent manner. In colon cancer cells, genistein induces G2/M phase cell cycle arrest and apoptosis, decreases the mitochondrial membrane potential, and inhibits cellular proliferation. In hepatocellular carcinoma cells, genistein decreases production of matrix metalloproteinase 9 (MMP9) and inhibits cellular invasion; it also downregulates hedgehog (Hh) signaling.

Product Info

Cas No.

446-72-0

Purity

≥98%

Formula

C15H10O5

Formula Wt.

270.24

Chemical Name

5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1- benzopyran-4-one

IUPAC Name

5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one

Synonym

Prunetol, Genisteol

Melting Point

297-298°C(slight dec.)

Solubility

Soluble in acetone or methanol. DMSO to 100 mM, ethanol to 2 mg/mL. Insoluble in water.

Appearance

Pale yellow crystalline powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G1652 MSDS PDF

Info Sheet

G1652 Info Sheet PDF

Brochures

Natural Products Booklet

References

Lee SH, Kim JK, Jang HD. Genistein inhibits osteoclastic differentiation of RAW 264.7 cells via regulation of ROS production and scavenging. Int J Mol Sci. 2014 Jun 12;15(6):10605-21. PMID: 24927148.

Wang S, Wei H, Cai M, et al. Genistein attenuates brain damage induced by transient cerebral ischemia through up-regulation of ERK activity in ovariectomized mice. Int J Biol Sci. 2014 Apr 8;10(4):457-65. PMID: 24719563.

Li J, Li J, Yue Y, et al. Genistein suppresses tumor necrosis factor α-induced inflammation via modulating reactive oxygen species/Akt/nuclear factor κB and adenosine monophosphate-activated protein kinase signal pathways in human synoviocyte MH7A cells. Drug Des Devel Ther. 2014 Mar 17;8:315-23. PMID: 24669186.

Wu J, Xu J, Han S, et al. Effects of genistein on apoptosis in HCT-116 human colon cancer cells and its mechanism. Wei Sheng Yan Jiu. 2014 Jan;43(1):1-5. PMID: 24564102.

Wang SD, Chen BC, Kao ST, et al. Genistein inhibits tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells. BMC Complement Altern Med. 2014 Jan 16;14:26. PMID: 24433534.

Fan P, Fan S, Wang H, et al. Genistein decreases the breast cancer stem-like cell population through Hedgehog pathway. Stem Cell Res Ther. 2013;4(6):146. PMID: 24331293.

Arunkumar E, Karthik D, Anuradha CV. Genistein sensitizes hepatic insulin signaling and modulates lipid regulatory genes through p70 ribosomal S6 kinase-1 inhibition in high-fat-high-fructose diet-fed mice. Pharm Biol. 2013 Jul;51(7):815-24. PMID: 23627466.

Luo S, Lan T, Liao W, et al. Genistein inhibits Aβ₂₅₋₃₅ -induced neurotoxicity in PC12 cells via PKC signaling pathway. Neurochem Res. 2012 Dec;37(12):2787-94. PMID: 22949092.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L8248

    Lumiracoxib

    NSAID; COX-2 inhibitor.

    ≥98%
  • T7156

    Tropisetron Hydrochloride

    α7 nAChR partial agonist, 5-HT3 antagonist.

    ≥98%
  • A1217

    Adefovir

    Acyclic nucleotide (adenosine) analog; viral DN...

    ≥98%
  • I761004

    Itaconic Acid

    Polymer precursor

    ≥99%
  • C760001

    CT-7001

    CDK7 inhibitor

    ≥99%
  • R2811

    Recombinant HIV-1 gp-41

    Recombinant HIV glycoprotein antigen fragment.<...

    ≥95%
  • E6825

    Ergosterol

    Sterol cell membrane component found in yeast a...

    ≥96%
  • M3377

    Mitomycin C

    Alkaloid produced by Streptomyces, DNA cross-li...

    ≥98%
  • T174441

    Telacebec

    Anti-tuberculosis

    ≥98%
  • T0101

    7-epi-10-Deacetyltaxol

    Taxane found in Taxus; potential microtubule de...

    ≥98%
  • A4441

    Allicin, aqueous solution

    Organosulfur found in garlic; Kir K+ channel ac...

    ≥98%
  • T7158

    Tropicamide

    mAChR antaonist.

    ≥98%
  • G0244

    alpha-Galactosylceramide

    Synthetic glycolipid found in Agelas mauritaniu...

    ≥96%
  • C0175

    Carbetocin Acetate

    Peptide, oxytocin analog; potential OXTR agonis...

    ≥95%
  • B8074

    3-tert-Butyl-5-Methoxy-1,2-quinone

    BHA derivative.

    ≥98%
  • S3368

    S1RA

    σ1 antagonist.

    ≥99%
  • V0352

    Vandetanib

    RET, EGFR, VEGFR2 inhibitor.

    ≥98%
  • M0040

    M40

    Peptide; galanin antagonist.

    ≥95%
  • G3351

    Ginkgolic Acid (17:1)

    Mixture of alkylphenols found in Ginkgo; HIV pr...

    ≥98%
  • C4533

    Clindamycin Phosphate

    Lincosamide; ribosomal translocation and protei...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only