Description
PF-07321332 (nirmatrelvir) is a protease inhibitor. It is considered a broad-spectrum inhibitor for coronaviruses.
PF-07321332
Product ID P200002
Cas No. 2628280-40-8
Purity ≥99%
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Product Info
| Cas No. | 2628280-40-8 |
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| Purity | ≥99% |
| Formula | C23H32F3N5O4 |
| Formula Wt. | 499.5 |
| Chemical Name | (1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide |
| IUPAC Name | (1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide |
| Synonym | Nirmatrelvir; 7R9A5P7H32; Paxlovid; PF07321332 |
| Appearance | White to off white powder |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
J A Mótyán, M Mahdi, G. Hoffka, et.al. Potential Resistance of SARS-CoV-2 Main Protease (Mpro) against Protease Inhibitors: Lessons Learned from HIV-1 Protease. Int J Mol Sci. 2022 Mar 23;23(7):3507.
S. Ullrich, K. B. Ekanayake, G. Otting, etl al. Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir. Bioorg Med Chem Lett 2022 Apr 15;62:128629. PMID: 35182772.
J. Li, C. Lin, X. Zhou, et al. Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332. J Virol. 2022 Apr 7;e0201321. doi: 10.1128/jvi.02013-21.