Clomipramine Hydrochloride

Name: Clomipramine Hydrochloride
SKU: C4457
Availability: InStock

Product ID C4457

Cas No. 17321-77-6

Purity ≥98%

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Description
Product Info
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References

Description

Clomipramine hydrochloride displays antidepressant and anxiolytic activity and may also be used to treat narcolepsy and obsessive-compulsive disorder (OCD). This compound inhibits serotonin transporters (SERT), norepinephrine transporters (NET), histamine receptors, muscarinic acetylcholine receptors(mAChRs), α1/2-adrenergic receptors, and 5-HT2/3/6/7 receptors. Clomipramine hydrochloride also inhibits L-type Ca2+ channels and exhibits antinociceptive activity in animal models of thermal and mechanical pain stimulation. Additionally, this compound may prolong the cardiac QT interval though its ability to decrease current amplitude from hERG K+ channels. Clomipramine also acts as a functional inhibitor of acid sphingomyelinase (FIASMA).

Product Info

Cas No.	17321-77-6
Purity	≥98%
Formula	C₁₉H₂₃ClN₂ • HCl
Formula Wt.	351.32
IUPAC Name	3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N, N-dimethylpropan-1-amine;hydrochloride
Melting Point	189-190°C
Solubility	Soluble in water (125 mg/ml), ethanol (70 mg/ml at 25° C), chloroform (1:3), DMSO (70 mg/ml at 25° C), and dilute aqueous acid
Appearance	White powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	C4457 MSDS PDF
Info Sheet	C4457 Info Sheet PDF

References

Kostadinov ID, Delev DP, Kostadinova II. Antinociceptive effect of clomipramine through interaction with serotonin 5-HT2 and 5-HT3 receptor subtypes. Folia Med (Plovdiv). 2012 Oct-Dec;54(4):69-77. PMID: 23441472.

Jo SH, Hong HK, Chong SH, et al. Clomipramine block of the hERG K+ channel: accessibility to F656 and Y652. Eur J Pharmacol. 2008 Sep 11;592(1-3):19-25. PMID: 18634780.

Zahradník I, Minarovic I, Zahradníková A. Inhibition of the cardiac L-type calcium channel current by antidepressant drugs. J Pharmacol Exp Ther. 2008 Mar;324(3):977-84. PMID: 18048694.

Millan MJ, Gobert A, Lejeune F, et al. S33005, a novel ligand at both serotonin and norepinephrine transporters: I. Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine. J Pharmacol Exp Ther. 2001 Aug;298(2):565-80. PMID: 11454918.

Greist JH, Jefferson JW, Kobak KA, et al. Efficacy and tolerability of serotonin transport inhibitors in obsessive-compulsive disorder. A meta-analysis. Arch Gen Psychiatry. 1995 Jan;52(1):53-60. PMID: 7811162.