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6-Aminonicotinamide inhibits glucose-6-phosphate dehydrogenase and suppresses activity in the pentose phosphate pathway. This compound exhibits potential anticancer benefit, inducing apoptosis and inhibiting the growth of cancer cells when combined with 2-deoxy-D-glucose. In vitro, 6-aminonicotinamide prevents maturation of oocytes.
| Cas No. | 329-89-5 |
|---|---|
| Purity | ≥98% |
| Formula | C6H7N3O |
| Formula Wt. | 137.14 |
| Chemical Name | 6-Aminopyridine-3-carboxamide |
| IUPAC Name | 6-aminopyridine-3-carboxamide |
| Synonym | 6-Aminopyridine-3-carboxamide |
| Melting Point | 245-248°C |
| Solubility | DMSO; or MeOH, 0.2/20, clear after heating |
| Appearance | White to off white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Parkhitko AA, Priolo C, Coloff JL, et al. Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. Mol Cancer Res. 2014 Jan;12(1):48-57. PMID: 24296756.
Alvarez GM, Ferretti EL, Gutnisky C, et al. Modulation of glycolysis and the pentose phosphate pathway influences porcine oocyte in vitro maturation. Reprod Domest Anim. 2013 Aug;48(4):545-53. PMID: 23189959.
Preuss J, Richardson AD, Pinkerton A, et al. Identification and characterization of novel human glucose-6-phosphate dehydrogenase inhibitors. J Biomol Screen. 2013 Mar;18(3):286-97. PMID: 23023104.
Bhardwaj R, Sharma PK, Jadon SP, et al. A combination of 2-deoxy-D-glucose and 6-aminonicotinamide induces cell cycle arrest and apoptosis selectively in irradiated human malignant cells. Tumour Biol. 2012 Aug;33(4):1021-30. PMID: 22328137.
