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6-Aminonicotinamide

6-Aminonicotinamide

Product ID A4940
Cas No. 329-89-5
Purity ≥98%
Product Unit SizeCostQuantityStock
250 mg $67.80 In stock
1 g $142.80 In stock
5 g $413.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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  • Downloads
  • References
  • Custom Order

Description

6-Aminonicotinamide inhibits glucose-6-phosphate dehydrogenase and suppresses activity in the pentose phosphate pathway. This compound exhibits potential anticancer benefit, inducing apoptosis and inhibiting the growth of cancer cells when combined with 2-deoxy-D-glucose. In vitro, 6-aminonicotinamide prevents maturation of oocytes.

Product Info

Cas No.

329-89-5

Purity

≥98%

Formula

C6H7N3O

Formula Wt.

137.14

Chemical Name

6-Aminopyridine-3-carboxamide

IUPAC Name

6-aminopyridine-3-carboxamide

Synonym

6-Aminopyridine-3-carboxamide

Melting Point

245-248°C

Solubility

DMSO; or MeOH, 0.2/20, clear after heating

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A4940 MSDS PDF

Info Sheet

A4940 Info Sheet PDF

References

Parkhitko AA, Priolo C, Coloff JL, et al. Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. Mol Cancer Res. 2014 Jan;12(1):48-57. PMID: 24296756.

Alvarez GM, Ferretti EL, Gutnisky C, et al. Modulation of glycolysis and the pentose phosphate pathway influences porcine oocyte in vitro maturation. Reprod Domest Anim. 2013 Aug;48(4):545-53. PMID: 23189959.

Preuss J, Richardson AD, Pinkerton A, et al. Identification and characterization of novel human glucose-6-phosphate dehydrogenase inhibitors. J Biomol Screen. 2013 Mar;18(3):286-97. PMID: 23023104.

Bhardwaj R, Sharma PK, Jadon SP, et al. A combination of 2-deoxy-D-glucose and 6-aminonicotinamide induces cell cycle arrest and apoptosis selectively in irradiated human malignant cells. Tumour Biol. 2012 Aug;33(4):1021-30. PMID: 22328137.

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