Bestatin Hydrochloride

Name: Bestatin Hydrochloride
SKU: B1874
Availability: InStock

Product ID B1874

Cas No. 65391-42-6

Purity ≥98%

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Description
Product Info
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References

Description

Bestatin is a dipeptide inhibitor of aminopeptidases such as aminopeptidase N/CD13. Bestatin displays efficacy in the treatment of lung cancer. This compound exhibits anticancer chemotherapeutic, immunomodulatory, and analgesic activities. Bestatin enhances differentiation of acute promyelocytic leukemia (APL) cells. Additionally, bestatin enhances proliferation of bone marrow macrophage progenitor cells and formation of CFU-GM colonies. This compound also inhibits catabolism of opioid endopeptides.

Product Info

Cas No.	65391-42-6
Purity	≥98%
Formula	C₁₆H₂₄N₂O₄ • HCl
Formula Wt.	344.87
Chemical Name	N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-L-leucine hydrochloride
IUPAC Name	(2S)-2-[[(2S, 3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid;hydrochloride
Synonym	Ubenimex hydrochloride
Melting Point	216-218°C
Solubility	Soluble in water (25mg.mL).
Appearance	White Crystal Powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	B1874 MSDS PDF
Info Sheet	B1874 Info Sheet PDF

References

Hitzerd SM, Verbrugge SE, Ossenkoppele G, et al. Positioning of aminopeptidase inhibitors in next generation cancer therapy. Amino Acids. 2014 Apr;46(4):793-808. PMID: 24385243.

Qian X, He J, Zhao Y, et al. Inhibition of p38 MAPK Phosphorylation Is Critical for Bestatin to Enhance ATRA-Induced Cell Differentiation in Acute Promyelocytic Leukemia NB4 Cells. Am J Ther. 2013 Oct 17. [Epub ahead of print]. PMID: 24141198.

Jia MR, Wei T, Xu WF. The Analgesic Activity of Bestatin as a Potent APN Inhibitor. Front Neurosci. 2010 Jun 28;4:50. PMID: 20631848.