• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Dihydrotanshinone

Dihydrotanshinone

Product ID D3330
Cas No. 87205-99-0
Purity ≥90%
Product Unit SizeCostQuantityStock
10 mg $204.30 In stock
25 mg $439.00 In stock
100 mg $1,327.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Dihydrotanshinone is found in Salvia that exhibits neuromodulatory, anticancer, anti-inflammatory, anti-allergic, anti-diabetic, antithrombotic, vasodilatory, antihypertensive, and anti-angiogenic activities. Dihydrotanshinone binds to the P-site of acetylcholinesterase (AChE), inhibiting its activity and showing potential benefit as a treatment for Alzheimer’s disease. Dihydrotanshinone also inhibits fatty acid synthase, mineralocorticoid receptors, and glucocorticoid receptors, suppressing expression of the Na+/K+ ATPase, G6Pase, and PEPCK; it also increases activation of AMPK. In colorectal cancer cells, dihydrotanshinone upregulates expression of ATF-3 and induces apoptosis, inhibiting proliferation. This compound also inhibits activation of AP-1 and NF-κB in vitro and suppresses passive cutaneous anaphylaxis in vivo by decreasing production of allergic mediators IL-4 and TNF-α. Dihydrotanshinone inhibits collagen-induced thromboxane B2 (TxB2) production and platelet aggregation in vitro. Additionally, dihydrotanshinone induces vascular relaxation in coronary artery rings in a Ca2+-dependent manner. This compound also inhibits migration, invasion, and tube formation in cellular and animal models of angiogenesis.

Product Info

Cas No.

87205-99-0

Purity

≥90%

Formula

C18H14O3

Formula Wt.

278.30

IUPAC Name

(1R)-1,6-dimethyl-1,2-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione

Melting Point

233-234°C

Solubility

Soluble in chloroform and acetone

Appearance

Red Crystal

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

D3330 MSDS PDF

Info Sheet

D3330 Info Sheet PDF

References

Cheung J, Beri V, Shiomi K, et al. Acetylcholinesterase Complexes with the Natural Product Inhibitors Dihydrotanshinone I and Territrem B: Binding Site Assignment from Inhibitor Competition and Validation Through Crystal Structure Determination. J Mol Neurosci. 2014 Feb 27. [Epub ahead of print]. PMID: 24573600.

Suk FM, Jou WJ, Lin RJ, et al. 15,16-Dihydrotanshinone I-induced apoptosis in human colorectal cancer cells: involvement of ATF3. Anticancer Res. 2013 Aug;33(8):3225-31. PMID: 23898083.

Jang TS, Zhang H, Kim G, et al. Bioassay-guided isolation of fatty acid synthase inhibitory diterpenoids from the roots of Salvia miltiorrhiza Bunge. Arch Pharm Res. 2012 Mar;35(3):481-6. PMID: 22477195.

Trinh HT, Chae SJ, Joh EH, et al. Tanshinones isolated from the rhizome of Salvia miltiorrhiza inhibit passive cutaneous anaphylaxis reaction in mice. J Ethnopharmacol. 2010 Oct 28;132(1):344-8. PMID: 20732401.

Liu Q, Zhang Y, Lin Z, et al. Danshen extract 15,16-dihydrotanshinone I functions as a potential modulator against metabolic syndrome through multi-target pathways. J Steroid Biochem Mol Biol. 2010 Jun;120(4-5):155-63. PMID: 20380878.

Lam FF, Yeung JH, Chan KM, et al. Dihydrotanshinone, a lipophilic component of Salvia miltiorrhiza (danshen), relaxes rat coronary artery by inhibition of calcium channels. J Ethnopharmacol. 2008 Sep 26;119(2):318-21. PMID: 18682284.

Park JW, Lee SH, Yang MK, et al. 15,16-dihydrotanshinone I, a major component from Salvia miltiorrhiza Bunge (Dansham), inhibits rabbit platelet aggregation by suppressing intracellular calcium mobilization. Arch Pharm Res. 2008 Jan;31(1):47-53. PMID: 18277607.

Bian W, Chen F, Bai L, et al. Dihydrotanshinone I inhibits angiogenesis both in vitro and in vivo. Acta Biochim Biophys Sin (Shanghai). 2008 Jan;40(1):1-6. PMID: 18180848.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G3253

    8-Gingerol

    Phenol found in Zingiber; 5-HT3 antagonist.

    ≥99%
  • A491337

    9-Aminocamptothecin Hydrochloride

    Derivative of camptothecin.

    ≥98%
  • A0964

    Adrenocorticotropic Hormone (1-13), human

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • G3453

    20(S)-Ginsenoside Rh2

    Triterpene saponin found in Panax.

    ≥98%
  • M568264

    Mogroside IIe

    Triterpenoid

    ≥98%
  • C2800

    Chalcone

    Enone.

    ≥97%
  • C000170

    C170

    STING inhibitor

    ≥98%
  • C1668

    Cerivastatin Sodium

    Statin; HMG-CoA reductase inhibitor.

    ≥98%
  • H174466

    Helvolic acid

    A fungal metabolite that inhibits protein synth...

    ≥98%
  • L1981

    Leucokinin VIII

    Peptide found in insects.

    ≥95%
  • B5609

    Boc-GRR-AMC

    Peptide, protease substrate.

    ≥98%
  • G7240

    GSK-2830371

    Wip1 inhibitor.

    ≥98%
  • C8017

    Cuelure

    Hormonal attractant for male Bactrocera flies.<...

    ≥97%
  • A7204

    AS-605240

    p110δ PI3K inhibitor.

    ≥98%
  • F8270

    Furosemide

    Loop diuretic; NKCC symporter inhibitor, CFTR C...

    ≥97%
  • M1879

    Metoprolol Tartrate

    β1-adrenergic antagonist.

    ≥98%
  • D3200

    Diacetoxyscirpenol

    Type A trichothecene mycotoxin produced by Fusa...

    ≥98%
  • S6168

    Spirapril Hydrochloride

    ACE inhibitor.

    ≥98%
  • C4510

    Climbazole

    14-α demethylase inhibitor.

    ≥99%
  • D1722

    Defactinib

    FAK inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only