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Dihydrotanshinone

Dihydrotanshinone

Product ID D3330
Cas No. 87205-99-0
Purity ≥90%
Product Unit SizeCostQuantityStock
10 mg $204.30 In stock
25 mg $439.00 In stock
100 mg $1,327.20 In stock
Bulk Quote

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  • Product Info
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  • Description
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Description

Dihydrotanshinone is found in Salvia that exhibits neuromodulatory, anticancer, anti-inflammatory, anti-allergic, anti-diabetic, antithrombotic, vasodilatory, antihypertensive, and anti-angiogenic activities. Dihydrotanshinone binds to the P-site of acetylcholinesterase (AChE), inhibiting its activity and showing potential benefit as a treatment for Alzheimer’s disease. Dihydrotanshinone also inhibits fatty acid synthase, mineralocorticoid receptors, and glucocorticoid receptors, suppressing expression of the Na+/K+ ATPase, G6Pase, and PEPCK; it also increases activation of AMPK. In colorectal cancer cells, dihydrotanshinone upregulates expression of ATF-3 and induces apoptosis, inhibiting proliferation. This compound also inhibits activation of AP-1 and NF-κB in vitro and suppresses passive cutaneous anaphylaxis in vivo by decreasing production of allergic mediators IL-4 and TNF-α. Dihydrotanshinone inhibits collagen-induced thromboxane B2 (TxB2) production and platelet aggregation in vitro. Additionally, dihydrotanshinone induces vascular relaxation in coronary artery rings in a Ca2+-dependent manner. This compound also inhibits migration, invasion, and tube formation in cellular and animal models of angiogenesis.

Product Info

Cas No.

87205-99-0

Purity

≥90%

Formula

C18H14O3

Formula Wt.

278.30

IUPAC Name

(1R)-1,6-dimethyl-1,2-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione

Melting Point

233-234°C

Solubility

Soluble in chloroform and acetone

Appearance

Red Crystal

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

D3330 MSDS PDF

Info Sheet

D3330 Info Sheet PDF

References

Cheung J, Beri V, Shiomi K, et al. Acetylcholinesterase Complexes with the Natural Product Inhibitors Dihydrotanshinone I and Territrem B: Binding Site Assignment from Inhibitor Competition and Validation Through Crystal Structure Determination. J Mol Neurosci. 2014 Feb 27. [Epub ahead of print]. PMID: 24573600.

Suk FM, Jou WJ, Lin RJ, et al. 15,16-Dihydrotanshinone I-induced apoptosis in human colorectal cancer cells: involvement of ATF3. Anticancer Res. 2013 Aug;33(8):3225-31. PMID: 23898083.

Jang TS, Zhang H, Kim G, et al. Bioassay-guided isolation of fatty acid synthase inhibitory diterpenoids from the roots of Salvia miltiorrhiza Bunge. Arch Pharm Res. 2012 Mar;35(3):481-6. PMID: 22477195.

Trinh HT, Chae SJ, Joh EH, et al. Tanshinones isolated from the rhizome of Salvia miltiorrhiza inhibit passive cutaneous anaphylaxis reaction in mice. J Ethnopharmacol. 2010 Oct 28;132(1):344-8. PMID: 20732401.

Liu Q, Zhang Y, Lin Z, et al. Danshen extract 15,16-dihydrotanshinone I functions as a potential modulator against metabolic syndrome through multi-target pathways. J Steroid Biochem Mol Biol. 2010 Jun;120(4-5):155-63. PMID: 20380878.

Lam FF, Yeung JH, Chan KM, et al. Dihydrotanshinone, a lipophilic component of Salvia miltiorrhiza (danshen), relaxes rat coronary artery by inhibition of calcium channels. J Ethnopharmacol. 2008 Sep 26;119(2):318-21. PMID: 18682284.

Park JW, Lee SH, Yang MK, et al. 15,16-dihydrotanshinone I, a major component from Salvia miltiorrhiza Bunge (Dansham), inhibits rabbit platelet aggregation by suppressing intracellular calcium mobilization. Arch Pharm Res. 2008 Jan;31(1):47-53. PMID: 18277607.

Bian W, Chen F, Bai L, et al. Dihydrotanshinone I inhibits angiogenesis both in vitro and in vivo. Acta Biochim Biophys Sin (Shanghai). 2008 Jan;40(1):1-6. PMID: 18180848.

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