| Product Unit Size | Cost | Quantity | Stock |
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AZD-0156 is an inhibitor of the ataxia-telangiectasia mutated (ATM) kinase. ATM is a member of the PIKK family, a family of kinases that are activated in response to DNA damage. ATM inhibition promotes survival in mice with chromosomal rearrangements of the MLL oncogene, a subtype of acute myeloid leukemia.
| Cas No. | 1821428-35-6 |
|---|---|
| Purity | ≥98% |
| Formula | C26H31N5O3 |
| Formula Wt. | 461.57 |
| IUPAC Name | 8-{6-[3-(Dimethylamino)propoxy]-3-pyridinyl}-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one |
| Synonym | AZD 0156, AZD0156 |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet |
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Moragdo-Palacin I., Day A., et al. Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML. Sci Signal. 9(445):ra91 (2016). PMID: 27625305.
