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K252a

K252a

Product ID K0021
Cas No. 99533-80-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $149.10 In stock
5 mg $504.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

K252a is an aglycone analog of staurosporine that acts as a protein kinase inhibitor, inhibiting PKC. K252a also inhibits TrkA/B receptors, suppressing activity of neurotrophins such as nerve growth factor (NGF).

Product Info

Cas No.

99533-80-9

Purity

≥98%

Formula

C27H21N3O5

Formula Wt.

467.48

IUPAC Name

methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylate

Synonym

SF 2370

Melting Point

262-263°C

Solubility

Readily soluble in chloroform, acetonitrile, acetone, dioxane, tetrahydrofuran, pyridine; soluble in ethanol, methanol, 1-propanol, ethyl acetate and n-butanol; insoluble in water, 2-propanol

Appearance

White Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

K0021 MSDS PDF

Info Sheet

K0021 Info Sheet PDF

References

El-Hashim AZ, Jaffal SM, Al-Rashidi FT, et al. Nerve growth factor enhances cough via a central mechanism of action. Pharmacol Res. 2013 Aug;74:68-77. PMID: 23742790.

Cardenas-Aguayo Mdel C, Kazim SF, Grundke-Iqbal I, et al. Neurogenic and neurotrophic effects of BDNF peptides in mouse hippocampal primary neuronal cell cultures. PLoS One. 2013;8(1):e53596. PMID: 23320097.

Sugiya H, Putney JW Jr. Protein kinase C-dependent and -independent mechanisms regulating the parotid substance P receptor as revealed by differential effects of protein kinase C inhibitors. Biochem J. 1988 Dec 1;256(2):677-80. PMID: 2464997.

Hashimoto S. K-252a, a potent protein kinase inhibitor, blocks nerve growth factor-induced neurite outgrowth and changes in the phosphorylation of proteins in PC12h cells. J Cell Biol. 1988 Oct;107(4):1531-9. PMID: 2844830.

Custom Order

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