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Melanotan II

Product ID M1650
Cas No. 121062-08-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $222.50 Please Inquire
10 mg $378.30 Please Inquire
25 mg $667.50 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Melanotan II is a synthetic melanocortin peptide analog that exhibits thermogenic, anti-inflammatory, and anti-atherosclerotic activities; it non-selectively binds melanocortin receptors. Melanotan II was originally designed to promote skin pigmentation, but has since been shown to induce arousal and increase body temperature in clinical settings and animal models. Melanotan II also decreases fluorodeoxyglucose uptake in atherosclerotic plaques, decreases pro-inflammatory cytokine levels, and increases aortic vasorelaxation in animal models of atherosclerosis.

Product Info

Cas No.

121062-08-6

Purity

≥98%

Formula

C50H69N15O9

Formula Wt.

1024.2

Chemical Name

L-Lysinamide,N-acetyl-L-norleucyl-L-alpha-aspartyl- L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl- ,cyclic (2-7)-peptide

IUPAC Name

(3S,6S,9R,12S,15S, 23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3- (diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H- indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13, 18-hexazacyclotricosane-23-carboxamide

Synonym

MT-II

Solubility

Soluble in water.

Appearance

White to off-white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

M1650 MSDS PDF

Info Sheet

M1650 Info Sheet PDF

References

Monge-Roffarello B, Labbé SM, Lenglos C, et al. The medial preoptic nucleus as a site of the thermogenic and metabolic actions of Melanotan II in male rats. Am J Physiol Regul Integr Comp Physiol. 2014 May 7. [Epub ahead of print]. PMID: 24808495.

Rinne P, Silvola JM, Hellberg S, et al. Pharmacological Activation of the Melanocortin System Limits Plaque Inflammation and Ameliorates Vascular Dysfunction in Atherosclerotic Mice. Arterioscler Thromb Vasc Biol. 2014 May 1. [Epub ahead of print]. PMID: 24790139.

Hjuler KF, Lorentzen HF. Melanoma associated with the use of melanotan-II. Dermatology. 2014;228(1):34-6. PMID: 24355990.

Hadley ME. Discovery that a melanocortin regulates sexual functions in male and female humans. Peptides. 2005 Oct;26(10):1687-9. PMID: 15996790.

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