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Thapsigargin

Product ID T2801
Cas No. 67526-95-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $122.10 In stock
5 mg $512.30 In stock
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  • Product Info
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  • References
  • Description
  • Product Info
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  • Downloads
  • References
  • Custom Order

Description

Thapsigargin is a sesquiterpene lactone found in Thapsia that is used in research models to induce endoplasmic reticulum (ER) stress. Thapsigargin inhibits SERCA Ca2+ pumps and may induce autophagy or apoptosis.

Product Info

Cas No.

67526-95-8

Purity

≥98%

Formula

C34H50O12

Formula Wt.

650.75

Chemical Name

Octanoic acid, 6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b- decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-((2- methyl-1-oxo-2-butenyl)oxy)-2-oxo-4-(1-oxobutoxy)- azuleno(4,5-b)furan-7-yl ester, (3S-(3α,3aβ,4α,6β,- 6aβ,7β,8α(Z),9bα))-

IUPAC Name

[(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-4-butanoyloxy-3, 3a-dihydroxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-4,5, 6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate

Synonym

Thapsigargine, Tg

Solubility

Soluble in DMSO, ethanol, or acetonitrile.

Appearance

Colorless film

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T2801 MSDS PDF

Info Sheet

T2801 Info Sheet PDF

References

Zhang X, Yuan Y, Jiang L, et al. Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury: Involvement of PARK2-dependent mitophagy. Autophagy. 2014 Oct 1;10(10):1801-13. PMID: 25126734.

Wang H, Jia XZ, Sui CJ, et al. Effects of thapsigargin on the proliferation and survival of human rheumatoid arthritis synovial cells. ScientificWorldJournal. 2014 Feb 9;2014:605416. PMID: 24688409.

Rogers TB, Inesi G, Wade R, et al. Use of thapsigargin to study Ca2+ homeostasis in cardiac cells. Biosci Rep. 1995 Oct;15(5):341-9. PMID: 8825036.

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