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Hexamethylene Bisacetamide

Product ID H1892
Cas No. 3073-59-4
Purity ≥99%
Product Unit SizeCostQuantityStock
25 g $72.90 In stock
50 g $116.30 In stock
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  • Description
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Description

Hexamethylene bisacetamide (HMBA) activates hexamethylene bisacetamide-inducible protein 1 (HEXIM1), inhibiting transcription elongation factor b (P-TEFb), a regulator of RNA polymerase II and mRNA synthesis. HMBA exhibits anticancer activity and is used to induce cellular differentiation and apoptosis in cancer cells. HMBA also inhibits activation of NF-κB, Akt, and ERK.

Product Info

Cas No.

3073-59-4

Purity

≥99%

Formula

C10H20N2O2

Formula Wt.

200.28

Chemical Name

N,N'-Hexamethylene (bis)acetamide

IUPAC Name

N-(6-acetamidohexyl)acetamide

Synonym

N,N'-Diacetyl-1,6-hexanediamine, HMBA

Melting Point

128-129°C

Solubility

Soluble in water or ethanol.

Appearance

White crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

H1892 MSDS PDF

Info Sheet

H1892 Info Sheet PDF

References

Lew QJ, Chia YL, Chu KL, et al. Identification of HEXIM1 as a positive regulator of p53. J Biol Chem. 2012 Oct 19;287(43):36443-54. PMID: 22948151.

Dey A, Wong E, Kua N, et al. Hexamethylene bisacetamide (HMBA) simultaneously targets AKT and MAPK pathway and represses NF kappaB activity: implications for cancer therapy. Cell Cycle. 2008 Dec;7(23):3759-67. PMID: 19029824.

Zhang Z, Liong EC, Lau TY, et al. Induction of apoptosis by hexamethylene bisacetamide is p53-dependent associated with telomerase activity but not with terminal differentiation. Int J Oncol. 2000 May;16(5):887-92. PMID: 10762623.

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