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Desvenlafaxine Succinate Hydrate

Desvenlafaxine Succinate Hydrate

Product ID D1874
Cas No. 386750-22-7
Purity ≥99%
Product Unit SizeCostQuantityStock
25 mg $75.10 In stock
100 mg $159.40 In stock
250 mg $306.20 In stock
1 g $918.80 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Desvenlafaxine is an active metabolite of venlafaxine, displaying neuromodulatory and antidepressant activities through its inhibition of serotonin and norepinephrine transporters (SERT, NET). Due to its modulation of serotonin levels, desvenlafaxine alters rates of gastric emptying; tolerance to this effect develops quickly during chronic administration. This compound is also in clinical trials as a potential treatment for menopausal hot flashes.

Product Info

Cas No.

386750-22-7

Purity

≥99%

Formula

C16H25NO2 • C4H6O4 • H2O

Formula Wt.

399.48

Chemical Name

4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-phenol succinate

IUPAC Name

butanedioic acid;4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol;hydrate

Synonym

Pristiq

Solubility

Soluble in water (50 mM), and DMSO (100 mM)

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D1874 MSDS PDF

Info Sheet

D1874 Info Sheet PDF

References

Song J, Yin J, Chen JD. Acute and chronic effects of desvenlafaxine on gastrointestinal transit and motility in dogs. Neurogastroenterol Motil. 2013 Jul 19. [Epub ahead of print]. PMID: 23865827.

Sun Z, Hao Y, Zhang M. Efficacy and safety of desvenlafaxine treatment for hot flashes associated with menopause: a meta-analysis of randomized controlled trials. Gynecol Obstet Invest. 2013;75(4):255-62. PMID: 23548358.

DeMartinis NA, Yeung PP, Entsuah R, et al. A double-blind, placebo-controlled study of the efficacy and safety of desvenlafaxine succinate in the treatment of major depressive disorder. J Clin Psychiatry. 2007 May;68(5):677-88. PMID: 17503976.

Deecher DC, Beyer CE, Johnston G, et al. Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor. J Pharmacol Exp Ther. 2006 Aug;318(2):657-65. PMID: 16675639.

Custom Order

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