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Bafilomycin B1

Bafilomycin B1

Product ID B0026
Cas No. 88899-56-3
Purity ≥97%
Product Unit SizeCostQuantityStock
0.5 mg $117.70 Please Inquire
1 mg $313.00 In stock
5 mg $1,001.90 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Bafilomycin B1 is a macrolide antibiotic that also exhibits antifungal activity. Bafilomycin B1 inhibits the vacuolar H+ ATPase. Additionally, bafilomycin B1 inhibits Foxo1 and increases β cell apoptosis, accelerating the onset of diabetes.

Product Info

Cas No.

88899-56-3

Purity

≥97%

Formula

C44H65NO13

Formula Wt.

815.99

Chemical Name

Hygrolidin,37-decarboxy-2-demethyl-37-(((2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino)carbonyl)-2-methoxy-24-methyl-

IUPAC Name

[(2R,4R,5S,6R)-2-hydroxy-2-[(2S,3R,4S)-3-hydroxy-4-[(3S,4Z,6Z,9S,10S, 11R,12Z,14E)-10-hydroxy-3,15-dimethoxy-7,9,11, 13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12, 14-tetraen-2-yl]pentan-2-yl]-5-methyl-6-propan-2-yloxan-4-yl] (E)-4-[(2-hydroxy-5-oxocyclopenten-1-yl)amino]-4-oxobut-2-enoate

Synonym

Setamycin

Melting Point

89-96°C (dec)

Solubility

Soluble in methanol.

Appearance

Yellow Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

B0026 MSDS PDF

Info Sheet

B0026 Info Sheet PDF

References

Schachtschabel D, Arentshorst M, Lagendijk EL, et al. Vacuolar H(+)-ATPase plays a key role in cell wall biosynthesis of Aspergillus niger. Fungal Genet Biol. 2012 Apr;49(4):284-93. PMID: 22222772.

Hettiarachchi KD, Zimmet PZ, Danial NN, et al. Transplacental exposure to the vacuolar-ATPase inhibitor bafilomycin disrupts survival signaling in beta cells and delays neonatal remodeling of the endocrine pancreas. Exp Toxicol Pathol. 2008 Aug;60(4-5):295-306. PMID: 18486461.

Custom Order

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