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Cefuroxime is a second generation semi-synthetic cephalosporin antibiotic that inhibits penicillin binding proteins. Cefuroxime is a β-lactam antibiotic that exhibits antibacterial activity against gram positive and gram negative bacteria, including species of Haemophilus, Enterobacteriaceae, Staphylococcus, and Klebsiella. Cefuroxime also displays immunomodulatory activity, as it downregulates expression of genes associated with Th2 and Treg differentiation in vitro.
| Cas No. | 56238-63-2 |
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| Purity | ≥98% |
| Formula | C16H15N4O8SNa |
| Formula Wt. | 446.37 |
| Chemical Name | Monosodium (6R, 7R)-3-carbamoyloxymethyl-7-[(Z)-2-furan-2-yl-2-methoxyiminoacetylamino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2carboxylate |
| IUPAC Name | sodium;(6R, 7R)-3-(carbamoyloxymethyl)-7-[[(2Z)-2-(furan-2-yl)-2-methoxyiminoacetyl] amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Solubility | Water, methanol |
| Appearance | White to yellowish crystalline powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Mor F, Cohen IR. Beta-lactam antibiotics modulate T-cell functions and gene expression via covalent binding to cellular albumin. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2981-6. PMID: 23382225.
Abdullah FE, Mushtaq A, Irshad M, et al. Current efficacy of antibiotics against Klebsiella isolates from urine samples - a multi-centric experience in Karachi. Pak J Pharm Sci. 2013 Jan;26(1):11-5. PMID: 23261722.
Sykes RB, Griffiths A, Ryan DM. Comparative acitivity of ampicillin and cefuroxime against three types of Haemophilus influenzae. Antimicrob Agents Chemother. 1977 Apr;11(4):599-604. PMID: 301007.
Eykyn S, Jenkins C, King A, et al. Antibacterial activity of cefuroxime, a new cephalosporin antibiotic, compared with that of cephaloridine, cephalothin, and cefamandole. Antimicrob Agents Chemother. 1976 Apr;9(4):690-5. PMID: 1267441.