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GDC-0349

Product ID G1310
Cas No. 1207360-89-1
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $137.20 In stock
5 mg $472.80 In stock
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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

GDC-0349 is an ATP-competitive inhibitor of mTOR that exhibits anticancer chemotherpeutic activity. GDC-0349 displays pre-clinical efficacy in vitro and in vivo.

Product Info

Cas No.

1207360-89-1

Purity

≥98%

Formula

C24H32N6O3

Formula Wt.

452.55

Chemical Name

1-ethyl-3-[4-[4-[(3S)-3-methylmorpholin-4-yl]-7-(oxetan-3-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]phenyl]urea

IUPAC Name

1-ethyl-3-[4-[4-[(3S)-3-methylmorpholin-4-yl]-7-(oxetan-3-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]phenyl]urea

Synonym

GDC0349

Solubility

DMSO 91 mg/mL (201.08 mM) Ethanol 6 mg/mL (13.25 mM) Water Insoluble

Appearance

Tan to yellow solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G1310 MSDS PDF

Info Sheet

G1310 Info Sheet PDF

Brochures

PI3K-Akt-mTORC Pathway Booklet

References

Pei Z, Blackwood E, Liu L, et al. Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349. ACS Med Chem Lett. 2012 Nov 29;4(1):103-7. PMID: 24900569.

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