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C-type natriuretic peptide (CNP) is an endogenous peptide expressed in the central nervous system, bone, and vasculature; CNP-22 is a mature form of CNP that is found predominantly in plasma. CNP exhibits vasodilatory, natriuretic, diuretic, and cardioprotective activities. CNP also exhibits anti-fibrotic potential, regulating cardiac hypertrophy and remodeling. This peptide inhibits the renin-angiotensin system, increasing endothelial permeability, and plays a role in bone growth.
| Purity | ≥95% |
|---|---|
| Formula | C93H157N27O28S3 |
| Formula Wt. | 2197.61 |
| Synonym | CNP |
| Solubility | Soluble in water (1 mg/mL). |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| Info Sheet |
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Del Ry S. C-type natriuretic peptide: a new cardiac mediator. Peptides. 2013 Feb;40:93-8. PMID: 23262354.
Calvieri C, Rubattu S, Volpe M. Molecular mechanisms underlying cardiac antihypertrophic and antifibrotic effects of natriuretic peptides. J Mol Med (Berl). 2012 Jan;90(1):5-13. PMID: 21826523.
Nishikimi T, Kuwahara K, Nakao K. Current biochemistry, molecular biology, and clinical relevance of natriuretic peptides. J Cardiol. 2011 Mar;57(2):131-40. Erratum in: J Cardiol. 2012 Jan;59(1):98-9. PMID: 21296556.
Del Ry S, Passino C, Emdin M, et al. C-type natriuretic peptide and heart failure. Pharmacol Res. 2006 Nov;54(5):326-33. PMID: 16904335.
