• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Tianeptine

Tianeptine

Product ID T3202
Cas No. 66981-73-5
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $102.70 In stock
50 mg $355.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Tianeptine is an agonist at μORs and δORs as well as a potentiator at D2 and D3 DA receptors. Tianeptine exhibits neuromodulatory, antidepressant, anxiolytic, analgesic, anticonvulsant, and anti-inflammatory activities, although its mechanism of action is not well understood. In vitro, tianeptine inhibits LPS-induced inflammation and activation of microglia; is also decreases pro-inflammatory cytokine release, ROS release, and NF-κB activation. Clinically, this compound improves anxiety symptoms, neurocognitive function, and memory. Tianeptine also attenuates mechanical allodynia, an effect that may be mediated by 5-HT7 receptors.

Product Info

Cas No.

66981-73-5

Purity

≥98%

Formula

C21H25ClN2O4S

Formula Wt.

436.95

Chemical Name

(1)-7-((3-Chloro-6,11-dihydro-6-methyldibenzo(c,f)(1,2)thiazepin-11-yl)amino)heptanoic acid S,S-dioxide

IUPAC Name

7-[(3-Chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid

Synonym

Tianeptine Acid; 7-[(3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl)amino]heptanoic acid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T3202 MSDS PDF

Info Sheet

T3202 Info Sheet PDF

References

Slusarczyk J, Trojan E, Glombik K, et al. Anti-inflammatory properties of tianeptine on lipopolysaccharide-induced changes in microglial cells involve Toll-like receptor-related pathways. J Neurochem. 2015 Dec 7. [Epub ahead of print]. PMID: 26640965.

Yoo I, Woo JM, Lee SH, et al. Influence of anxiety symptoms on improvement of neurocognitive functions in patients with major depressive disorder: A 12-week, multicenter, randomized trial of tianeptine versus escitalopram, the CAMPION study. J Affect Disord. 2015 Oct 1;185:24-30. PMID: 26142691.

Lin H, Heo BH, Kim WM, et al. Antiallodynic effect of tianeptine via modulation of the 5-HT7 receptor of GABAergic interneurons in the spinal cord of neuropathic rats. Neurosci Lett. 2015 Jun 26;598:91-5. PMID: 25982324.

Cooper CM, Whiting DA, Cowen PJ, et al. Tianeptine in an experimental medicine model of antidepressant action. J Psychopharmacol. 2015 May;29(5):582-90. PMID: 25759404.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S0225

    SAG Dihydrochloride

    Smoothened agonist.

    ≥98%
  • P3563

    Piperlonguminine

    Found in Piper longum.

    ≥99%
  • G880000

    GW 405833

    Cannabinoid receptor 2 selective agonist.

    ≥98%
  • G5216

    GNE-7915

    LRRK2 inhibitor.

    ≥98%
  • A454470

    L-Allylglycine

    Inhibitor of glutamic acid decarboxylase (GAD)....

    ≥98%
  • C0016

    Caerulomycin A

    Bipyridamine toxin.

    ≥96%
  • C4557

    Clofibrate

    Fibrate; PPARα agonist.

    ≥99%
  • T342710

    Tirzepatide

    GLP-1/GIP receptor co-agonist

    ≥98%
  • W0269

    (±)-Warfarin

    Coumarin; VKORC1 inhibitor.

    ≥98%
  • S822687

    Surfactin

    Amphiphilic properties

    ≥90% mixed isomers
  • S6019

    Speract

    Peptide, derived from egg outer envelope; K+ ch...

    ≥95%
  • L582694

    Lorlatinib

    Third generation macrocyclic ALK inhibitor.

    ≥98%
  • C0263

    L-Carnitine Hydrochloride

    Endogenous quaternary ammonium, required for fa...

    ≥98%
  • S1606

    Secretin, porcine

    Endogenous peptide hormone, involved in water h...

    ≥95%
  • M0172

    Mastoparan

    Antimicrobial peptide found in Vespula lewisii,...

    ≥95%
  • D0010

    3H-1,2-Dithiole-3-thione

    Induces activation of Nrf2; inhibits apoptosis ...

    ≥98%
  • G4796

    Glycerol Monolaurate

    Surfactant found in coconut oil.

    ≥98%
  • V3455

    Vinpocetine

    Targets nuclear factor kappa B activation.

    ≥98%
  • C0140

    Calcitonin, eel

    Endogenous neuropeptide hormone, lowers extrace...

    ≥95%
  • R1776

    Resveratrol

    Phenolic phytoalexin found in soy, grapes, and ...

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only