• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
3H-1,2-Dithiole-3-thione

3H-1,2-Dithiole-3-thione

Product ID D0010
Cas No. 534-25-8
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $104.10 In stock
100 mg $347.10 In stock
500 mg $1,371.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

3H-1,2-dithiole-3-thione (D3T) is a phase II enzyme inducer and sulfur donor originally found in cruciferous vegetables; it exhibits antioxidative, neuroprotective, and chemopreventive activities. In vitro, D3T increases levels of glutathione and activity of NADH quinone oxidoreductase (NQO1), protecting cells against H2O2-induced toxicity. D3T also induces activation of Nrf2, inhibiting ethanol-induced apoptosis in neurons. Additionally, this compound inhibits the formation of DNA adducts by DBP in breast cancer cells.

Product Info

Cas No.

534-25-8

Purity

≥98%

Formula

C3H2S3

Formula Wt.

134.25

IUPAC Name

dithiole-3-thione

Synonym

D3T, 1,2-Dithiol-3-thione

Solubility

Insoluble in water. Soluble in DMSO (≥10 mg/ml).

Appearance

Dark red crystals

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D0010 MSDS PDF

Info Sheet

D0010 Info Sheet PDF

References

Jia J, Xiao Y, Wang W, et al. Differential mechanisms underlying neuroprotection of hydrogen sulfide donors against oxidative stress. Neurochem Int. 2013 Jun;62(8):1072-8. PMID: 23587562.

Pazdro R, Burgess JR. The antioxidant 3H-1,2-dithiole-3-thione potentiates advanced glycation end-product-induced oxidative stress in SH-SY5Y cells. Exp Diabetes Res. 2012;2012:137607. PMID: 22675339.

Dong J, Yan D, Chen SY. Stabilization of Nrf2 protein by D3T provides protection against ethanol-induced apoptosis in PC12 cells. PLoS One. 2011 Feb 3;6(2):e16845. PMID: 21304811.

Kwak MK, Egner PA, Dolan PM, et al. Role of phase 2 enzyme induction in chemoprotection by dithiolethiones. Mutat Res. 2001 Sep 1;480-481:305-15. PMID: 11506823.

Pillon NJ, Croze ML, Vella RE, et al. The lipid peroxidation by-product 4-hydroxy-2-nonenal (4-HNE) induces insulin resistance in skeletal muscle through both carbonyl and oxidative stress. Endocrinology. 2012 May;153(5):2099-2111. PMID: 22396448.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • V1668

    Vemurafenib

    B-Raf inhibitor.

    ≥98%
  • A5033

    4-Aminosalicylic Acid

    Dihydrofolate reductase inhibitor.

    ≥98%
  • C9881

    Cytochalasin D

    Mycotoxin produced by Aspergillus; actin polyme...

    ≥98%
  • I4802

    Imatinib Mesylate

    Abl, c-Kit, PDGFR inhibitor.

    ≥98%
  • V1868

    Veratramine

    Steroidal alkaloid found in Veratrum and Fritil...

    ≥98%
  • B1870

    Berberine Chloride

    Isoquinoline alkaloid found in various plant so...

    ≥97%
  • T0154

    Tanshinone IIA

    Found in Salvia; MAG lipase inhibitor.

    ≥93%
  • D1695

    Dexamethasone Phosphate Sodium

    Steroid; glucocorticoid agonist.

    ≥98%
  • C1868

    Cerebellin

    Peptide, involved in synapse formation and cell...

    ≥95%
  • Z5653

    Zonisamide

    Sulfonamide; carbonic anhydrase inhibitor, volt...

    ≥96%
  • G0245

    Gallocatechin Gallate

    Polyphenol found in Camilla sinensis; HIV integ...

    ≥98%
  • A0977

    Actinomycin

    Polypeptide antibiotic produced from Streptomyc...

    ≥98%
  • B0245

    Balicatib

    Cathepsin K inhibitor.

    ≥98%
  • A1331

    Adipokinetic Hormone, locust

    Neuropeptide hormone found in insects, involved...

    ≥95%
  • H3273

    Histatin 5

    Endogenous antimicrobial peptide, binds bacteri...

    ≥95%
  • T3098

    Thymosin β-4 Acetate

    Endogenous peptide; actin polymerization inhibi...

    ≥95%
  • C3262

    Ciprofloxacin

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • K0282

    Kavalactones Mixture

    Mixture of kavalactones found in Piper methysti...

    ≥98%
  • L961000

    LY-3295668

    Aurora kinase A inhibitor

    ≥99%
  • T8153

    Tunicamycin

    Nucleoside antibiotic mixture; GlcNAc phosphotr...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only