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Oxytocin is an endogenous peptide neurohormone that does not cross the blood-brain barrier. Oxytocin binds the oxytocin receptor (OXTR) and exhibits neuromodulatory, antinociceptive, antidepressant, anxiolytic, and other activities; it is involved with feelings of trust, memory, intimacy, and fidelity. Oxytocin also inhibits acid-sensing ion channels and may be used as a biomarker of bone mineral density.
| Cas No. | 50-56-6 |
|---|---|
| Purity | ≥95% |
| Formula | C43H66N12O12S2 |
| Formula Wt. | 1007.2 |
| Chemical Name | L-Cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L- asparaginyl-L-cysteinyl-L-prolyl-L-leucylglycinamide cyclic (1-6)-disulfide |
| IUPAC Name | 1-[19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-butan-2- yl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11, 14, 17-pentazacycloicosane-4-carbonyl]-N-[1-[(2-amino-2-oxoethyl)amino]-4- methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide |
| Synonym | Ocytocin, Interocine-S, Perlacton, Pitocin, Syntocinon, Orasthin, Oxystin, Partocon. |
| Melting Point | 192-194°C |
| Solubility | Soluble in water (1 mg/mL), 1-butanol or 2-butanol, ethanol, DMSO, DMF. |
| Appearance | White to off-white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Breuil V, Panaia-Ferrari P, Fontas E, et al. Oxytocin, a new determinant of bone mineral density in post-menopausal women: analysis of the OPUS cohort. J Clin Endocrinol Metab. 2014 Apr;99(4):E634-41. PMID: 24446658.
Yuen KW, Garner JP, Carson DS, et al. Plasma oxytocin concentrations are lower in depressed vs. healthy control women and are independent of cortisol. J Psychiatr Res. 2014 Apr;51:30-6. PMID: 24405552.
Qiu F, Qiu CY, Cai H, et al. Oxytocin inhibits the activity of acid-sensing ion channels through the vasopressin-1a receptor in primary sensory neurons. Br J Pharmacol. 2014 Feb 15. [Epub ahead of print]. PMID: 24641084.
Evans SL, Dal Monte O, Noble P, et al. Intranasal oxytocin effects on social cognition: A critique. Brain Res. 2013 Nov 14. [Epub ahead of print]. PMID: 24239931.
