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Lonidamine

Product ID L5658
Cas No. 50264-69-2
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $102.70 In stock
25 mg $183.80 In stock
100 mg $735.50 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Lonidamine inhibits glycolysis by inhibiting hexokinases; it exhibits anti-aging, anti-parasitic, and anti-fertility activities. Lonidamine increases lifespan in Caenorhabditis elegans, increasing stress resistance and promoting mitochondrial respiration by increasing levels of ROS. Lonidamine also displays antibiotic activity, causing death in Trypanosoma. In vivo, lonidamine increases testes weight and decreases sperm count and testosterone levels.

Product Info

Cas No.

50264-69-2

Purity

≥98%

Formula

C15H10Cl2N2O2

Formula Wt.

321.16

Chemical Name

1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid

IUPAC Name

1-[(2,4-dichlorophenyl)methyl]indazole-3-carboxylic acid

Synonym

Diclondazolic acid, DICA, AF-1890, Doridamina.

Melting Point

207°C

Solubility

Soluble in methanol or acetic acid.

Appearance

White or off-white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

L5658 MSDS PDF

Info Sheet

L5658 Info Sheet PDF

References

Schmeisser S, Zarse K, Ristow M. Lonidamine extends lifespan of adult Caenorhabditis elegans by increasing the formation of mitochondrial reactive oxygen species. Horm Metab Res. 2011 Sep;43(10):687-92. PMID: 21932172.

Chambers JW, Fowler ML, Morris MT, et al. The anti-trypanosomal agent lonidamine inhibits Trypanosoma brucei hexokinase 1. Mol Biochem Parasitol. 2008 Apr;158(2):202-7. PMID: 18262292.

Traina ME, Guarino M, Natoli A, et al. Lonidamine affects testicular steroid hormones in immature mice. Toxicol Appl Pharmacol. 2007 May 15;221(1):95-101. PMID: 17442358.

Ditonno P, Battaglia M, Selvaggio O, et al. Clinical Evidence Supporting the Role of Lonidamine for the Treatment of BPH. Rev Urol. 2005;7 Suppl 7:S27-33. PMID: 16986058.

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