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Aniracetam

Aniracetam

Product ID A5326
Cas No. 72432-10-1
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $71.50 In stock
100 mg $156.80 In stock
500 mg $469.10 In stock
1 g $763.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Aniracetam is a nootropic ampakine that exhibits anxiolytic and neuroprotective activities. Aniracetam acts as a positive allosteric modulator of AMPA receptors, slowing receptor deactivation; it also acts on D2 receptors, 5-HT2A receptors, and nicotinic acetylcholine receptors (nAChRs), likely displaying agonist activity. Aniracetam decreases anxiety in vivo in the condition fear stress test, elevated plus maze test, and in social interaction tests. Additionally, this compound inhibits H2O2-induced deficits in long-term potentiation and neuron viability. Aniracetam shows some clinical benefit in the enhancement of cognitive deficits associated with stroke and Alzheimer’s disease.

Product Info

Cas No.

72432-10-1

Purity

≥98%

Formula

C12H13NO3

Formula Wt.

219.24

Chemical Name

1-(4-Methoxybenzoyl)-2-pyrrolidinone

IUPAC Name

1-(4-methoxybenzoyl)pyrrolidin-2-one

Synonym

Ro-13-5057, Draganon, Sarpul  

Melting Point

121-122°C

Solubility

Soluble in chloroform and ethyl acetate. Slightly soluble in ethanol. Insoluble in water.

Appearance

White or almost White Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A5326 MSDS PDF

Info Sheet

A5326 Info Sheet PDF

References

Wang YF, Li CC, Cai JX. Aniracetam attenuates H2O2-induced deficiency of neuron viability, mitochondria potential and hippocampal long-term potentiation of mice in vitro. Neurosci Bull. 2006 Sep;22(5):274-80. PMID: 17690727.

Jin R, Clark S, Weeks AM, et al. Mechanism of positive allosteric modulators acting on AMPA receptors. J Neurosci. 2005 Sep 28;25(39):9027-36. PMID: 16192394.

Nakamura K. Aniracetam: its novel therapeutic potential in cerebral dysfunctional disorders based on recent pharmacological discoveries. CNS Drug Rev. 2002 Spring;8(1):70-89. PMID: 12070527.

Nakamura K, Kurasawa M. Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. Eur J Pharmacol. 2001 May 18;420(1):33-43. PMID: 11412837.

Ito I, Tanabe S, Kohda A, et al. Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam. J Physiol. 1990 May;424:533-43. PMID: 1975272.

Custom Order

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