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Roscovitine

Product ID R5774
Cas No. 186692-46-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $88.30 In stock
5 mg $175.30 In stock
10 mg $259.50 In stock
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  • Product Info
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  • Description
  • Product Info
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Description

Roscovitine is an inhibitor of CDKs (1, 2, 5, 7, 9, 12) and L-type Ca2+ channels; it exhibits anti-inflammatory and anticancer activities. Roscovitine resolves neutrophil-driven inflammation. In B-cell lymphoma cells, roscovitine induces cell cycle arrest and apoptosis and inhibits proliferation.

Product Info

Cas No.

186692-46-6

Purity

≥98%

Formula

C19H26N6O

Formula Wt.

354.45

Chemical Name

2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino- 9-isopropylpurine

IUPAC Name

DISCONTINUED

Synonym

Seliciclib, CYC202

Melting Point

106-109°C

Solubility

Soluble in DMSO or chloroform.

Appearance

White crystalline solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

R5774 MSDS PDF

Info Sheet

R5774 Info Sheet PDF

References

Leitch AE, Haslett C, Rossi AG. Cyclin-dependent kinase inhibitor drugs as potential novel anti-inflammatory and pro-resolution agents. Br J Pharmacol. 2009 Oct;158(4):1004-16. PMID: 19775281.

Yarotskyy V, Elmslie KS. Roscovitine, a cyclin-dependent kinase inhibitor, affects several gating mechanisms to inhibit cardiac L-type (Ca(V)1.2) calcium channels. Br J Pharmacol. 2007 Oct;152(3):386-95. PMID: 17700718.

Lacrima K, Rinaldi A, Vignati S, et al. Cyclin-dependent kinase inhibitor seliciclib shows in vitro activity in diffuse large B-cell lymphomas. Leuk Lymphoma. 2007 Jan;48(1):158-67. PMID: 17325859.

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