• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
AK-1

AK-1

Product ID A4000
Cas No. 330461-64-8
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $81.90 In stock
10 mg $157.50 In stock
25 mg $330.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

AK-1 is an inhibitor of sirtuin 2 (SIRT2); sirtuins are considered class III histone deacetylases (HDACs). AK-1 exhibits neuroprotective and anticancer activities. This compound prevents some hippocampal neurodegeneration in animal models of Alzheimer’s disease. AK-1 also induces cell cycle arrest in colon carcinoma cells by downregulating expression of Snail.

Product Info

Cas No.

330461-64-8

Purity

≥99%

Formula

C19H21N3O5S

Formula Wt.

403.45

IUPAC Name

3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide

Synonym

SIRT2 inhibitor II

Solubility

Soluble in DMSO

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A4000 MSDS PDF

Info Sheet

A4000 Info Sheet PDF

References

Cheon MG, Kim W, Choi M, et al. AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells. Cancer Lett. 2015 Jan 28;356(2 Pt B):637-45. PMID: 25312940.

Spires-Jones TL, Fox LM, Rozkalne A, et al. Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia. Front Pharmacol. 2012 Mar 12;3:42. PMID: 22416232.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T7133

    Trimetazidine Dihydrochloride

    Long-chain 3-ketoacyl-CoA thiolase inhibitor, p...

    ≥99%
  • L8261

    Lupeol

    Triterpene; potential tyrosinase inhibitor.

    ≥98%
  • N3448

    Nimodipine

    L-type Ca2+ channel blocker.

    ≥98%
  • I2056

    Ifosfamide

    Nitrogen mustard, DNA alkylator.

    ≥98%
  • V1870

    Verruculogen

    Mycotoxin produced by Aspergillus; BK K+ channe...

    ≥95%
  • M3576

    Mitotane

    Diphenylmethane, inhibits secretion of cortisol...

    ≥98%
  • W0270

    (±)-Warfarin Sodium Clathrate

    Coumarin; VKORC1 inhibitor.

    ≥98%
  • G7200

    GS-967

    Na+ channel blocker.

    ≥98%
  • I7757

    Itopride Hydrochloride

    AChE inhibitor, D2 antagonist.

    ≥98%
  • M2076

    Metformin Hydrochloride

    AMPK activator.

    ≥98%
  • S1848

    Se-Methylseleno-L-cysteine

    Found in plants in Astragalus, Allium, and Bras...

    ≥98%
  • E4902

    Emamectin B1 Benzoate

    Semi-synthetic avermectin; GABA potentiator.

    ≥80%
  • S8246

    Sulfadimethoxine

    Sulfonamide; folic acid synthesis inhibitor.

    ≥98%
  • D0025

    DAMGO

    Synthetic peptice; μOR agonist.

    ≥95%
  • H978583

    Hyoscyamine sulfate dihydrate

    Tropane alkaloid found in plants in the Solanac...

    ≥99%
  • M1745

    Melatonin

    Endogenous hormone involved in circadian rhythm...

    ≥98%
  • E2542

    Met-Enkephalin Amide

    Endogenous opioid peptide; δOR and μOR agonis...

    ≥95%
  • A3208

    AICAR

    AMPK activator.

    ≥98%
  • D3209

    Diclofenac Sodium

    NSAID; COX-1/2 inhibitor, potential K+ channel ...

    ≥99%
  • G1849

    Gemifloxacin Mesylate

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only