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AK-1

Product ID A4000
Cas No. 330461-64-8
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $111.80 In stock
10 mg $188.40 In stock
25 mg $347.30 In stock
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  • Product Info
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
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Description

AK-1 is an inhibitor of sirtuin 2 (SIRT2); sirtuins are considered class III histone deacetylases (HDACs). AK-1 exhibits neuroprotective and anticancer activities. This compound prevents some hippocampal neurodegeneration in animal models of Alzheimer’s disease. AK-1 also induces cell cycle arrest in colon carcinoma cells by downregulating expression of Snail.

Product Info

Cas No.

330461-64-8

Purity

≥99%

Formula

C19H21N3O5S

Formula Wt.

403.45

IUPAC Name

3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide

Synonym

SIRT2 inhibitor II

Solubility

Soluble in DMSO

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A4000 MSDS PDF

Info Sheet

A4000 Info Sheet PDF

References

Cheon MG, Kim W, Choi M, et al. AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells. Cancer Lett. 2015 Jan 28;356(2 Pt B):637-45. PMID: 25312940.

Spires-Jones TL, Fox LM, Rozkalne A, et al. Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia. Front Pharmacol. 2012 Mar 12;3:42. PMID: 22416232.

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