LKT Labs

Biochemicals for Life Science Research

Se-Methylseleno-L-cysteine

Product ID S1848
Cas No. 26046-90-2
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $189.90 In stock
250 mg $379.80 In stock
Bulk Quote

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Description

Methylselenocysteine is found in plants in the Astragalus, Allium, and Brassica genera; it exhibits cytoprotective, chemopreventive, anti-angiogenic, antioxidative, and anti-inflammatory activities. Methylselenocysteine induces phase II enzyme activity and protects organs against chemotherapy-induced toxicity. In other models, methylselenocysteine increases expression of Nrf2, heme oxygenase 1 (HO-1), catalase, and glutathione-S-transferase, protecting against radiation-induced oxidative damage. Additionally, this compound decreases activation of NF-κB, p38 MAPK, and JNK and decreases expression of iNOS in LPS-stimulated macrophages.

Product Info

Cas No.

26046-90-2
Purity

≥98%
Formula

C4H9NO2Se

Formula Wt.

182.08
Chemical Name

3-(methylseleno)-L-alanine
IUPAC Name

(2R)-2-amino-3-methylselanylpropanoic acid
Synonym

Methylselenocysteine, Selenium-methylselenocystine, 2-Amino-3-methylselenyl propionic acid
Solubility

Soluble in water (5 mg/mL).
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

S1848 MSDS PDF
Info Sheet

S1848 Info Sheet PDF

References

Cao S, Durrani FA, Tóth K, et al. Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models. Br J Cancer. 2014 Apr 2;110(7):1733-43. PMID: 24619073.

Shin HS, Yang WJ, Choi EM. The preventive effect of Se-methylselenocysteine on γ-radiation-induced oxidative stress in rat lungs. J Trace Elem Med Biol. 2013 Apr;27(2):154-9. PMID: 23176811.

Bhattacharya A. Methylselenocysteine: a promising antiangiogenic agent for overcoming drug delivery barriers in solid malignancies for therapeutic synergy with anticancer drugs. Expert Opin Drug Deliv. 2011 Jun;8(6):749-63. PMID: 21473705.

Pan MH, Hong HM, Lin CL, et al. Se-methylselenocysteine inhibits lipopolysaccharide-induced NF-κB activation and iNOS induction in RAW 264.7 murine macrophages. Mol Nutr Food Res. 2011 May;55(5):723-32. PMID: 21213327.

Zhang J, Wang L, Anderson LB, et al. Proteomic profiling of potential molecular targets of methyl-selenium compounds in the transgenic adenocarcinoma of mouse prostate model. Cancer Prev Res (Phila). 2010 Aug;3(8):994-1006. PMID: 20647336.

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